摘要
目的:探讨乳腺癌患者血清中转化生长因子β1(TGFβ1)、白细胞介素6(IL-6)和白细胞介素2(IL-2)的变化及其临床意义。方法:采用放射免疫分析(RIA)法测定28例乳腺癌患者、11例乳腺良性疾病患者和30例健康妇女血清TGFβ1、IL-6和IL-2的水平。结果:乳腺癌患者血清TGFβ1和IL-6活性水平均高于乳腺良性病变组及对照组(P<0.05),而IL-2活性水平则明显降低(P<0.05)。结论:乳腺癌患者血清中TGFβ1和IL-6活性水平升高及IL-2活性水平降低可能与乳腺癌发生、发展有关,测定其水平可作为临床病情观察和评估疗效的辅助手段。
Objective： To study the changes and clinical significance of serum TGFβ1 , IL -6 and IL -2 levels in patients with breast cancer. Methods： The serum levels of TGFβ1 , IL -6 and IL - 2 were detected by RIA in 38 cases of breast cancer, llcases of benign breast diseases ano 30 normal controls. Results ： The serum levels of TGFβ1 and IL - 6 were significantly higher, but the level of IL - 2 was significantly lower in patients with breast cancer than in patients with benign breast diseases and normal controls. Conelusion： The activity of serum TGFβ1, IL - 6 and IL - 2 may related with development of the breast cancer. The determination of TGFβ1, IL - 6 and IL - 2 in serum can be helpful to observation of the breast cancer state as a supplementary methods.
出处
《中国妇幼保健》
CAS
北大核心
2007年第18期2482-2483,共2页
Maternal and Child Health Care of China
