摘要
目的探讨系统性红斑狼疮（SLE）患者血清泌乳素（PRL）与性激素水平的关系。方法对46例系统性红斑狼疮患者采用电化学发光分析仪检测血清泌乳素和各种性激素的含量，并进行分析。结果（1）SLE患者与对照组比较，PRL水平差异有统计学意义（P〈0．01），雌二醇（E2）水平差异有统计学意义（P〈0．05），黄体生成素（LH）、睾酮（T）水平差异有统计学意义（P〈0．05），E2／T各组均高于正常组。（2）SLE活动期患者与对照组比较，PRL、E2水平差异有统计学意义（P〈0．01），LH、E2差异有统计学意义（P〈0．01）。（3）SLE活动期与非活动期比较，PRL水平差异有统计学意义（P〈0．01），E2、T、LH水平差异有统计学意义（P〈0．05）。结论SLE患者血清PRL水平与E2、T、LH水平的相关分析显示，46例患者血清PRL水平与活动期E2的水平呈正相关（P〈0．05），与LH水平呈负相关（P〈0．05），与T水平呈负相关性。本组研究证明，PRL和E2对SLE的发病起着重要的相关作用，提示PRL和E2测定对SLE诊断、病程观察及预后有重要临床意义。
To investigate the relationship between serum prolactin and sex hormones in patients with systemic lupus erythematosus. Methods Serum prolactin level and various sex hormones were measured by electrochemiluminescence analysis in 46 patients with systemic lupus erythematosus. Results （1） There were statistical differences of PRL （P〈0.01）, E2 （P〈0.05）, LH and T （P〈0.05） between SLE group and control group. The levels of E2 and T were higher significantly in SLE group than that in control group. （2） There were statistical differences of PRL, LH and E2 （P〈0.01） between active SLE group and control group. （3） There were statistical differences of PRL （P〈0.01）, E2, T and LH （P〈0.05） between active SLE group and non-active SLE group. Conclusion Serum PRL level positively correlates with E2 level in active SLE patients （P〈0.05）, and negatively correlates with LH and T in 46 patients. This study shows PRL and E2 attribute to the incidence of SLE. PRL and E2 detection plays an important role in SLE diagnosis, disease duration observation and prognosis evaluation.
出处
《国际检验医学杂志》
CAS
2007年第6期525-526,共2页
International Journal of Laboratory Medicine
关键词
红斑狼疮
系统性
催乳素
雌二醇
促黄体激素
睾酮
Lupus erythematosus,systemic
Prolactin
Estradiol
Luteinizing hormone
Testosterone
