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急性心肌梗死直接经皮冠状动脉介入治疗后无复流存活患者心功能的近期随访结果 被引量：2

Clinical follow-up study of no-reflow phenomenon in acute myocardial infarction patients after direct percutaneous intervention.
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摘要 目的评估直接经皮冠状动脉介入治疗(PCI)后无复流存活患者心功能的近期随访结果。方法1999年3月至2006年6月共对557例ST段抬高心肌梗死(STEMI)(男449例,女108例)患者施行直接PCI。其中32例发生无复流而存活患者可供随访,简称无复流存活组。选择2005年1月至2005年6月临床基线特征和血管造影特征与无复流存活组匹配的45例患者作为对照组。随访指标:3个月和6个月超声心动图心功能状态以及病死率。结果①术后3个月随访显示,无复流存活组和对照组的左心室射血分数分别为0.38±0.11和0.49±0.10(P<0.05),病死率分别为6.3%和0。②术后6个月随访显示,无复流存活组和对照组的左心室射血分数分别为0.39±0.12和0.50±0.11,P<0.05,病死率分别为12.5%和2.2%。结论STEMI直接PCI发生无复流患者的住院病死率高,无复流存活患者的近中期病死率高,并且心功能状态明显较没有发生无复流的存活患者差。提示预防直接PCI时发生无复流,是临床亟待解决的一个问题。 Objective To study the the clinical short term follow-up heart function outcome of no-reflow phenomenon in patients with acute myocardial infarction after emergency percutaneous intervention （ PCI ）. Methods 557 patients with STEMI were referred for emergency PCI from March 1999 to February 2006. No-reflow occurred in 32 patients. 32 survivals followed up were called no-reflow survival group. 45 patients of clinical baseline feature and anglography feature matching with no-reflow survival group were enroUed as control group. The follow up data：in cluded 3 month and 6 month heart function examination by ultrasonic cardiogram （ UCG ） and mortality rate. Results （1） 3 months UCG data suggested that LVEF in no-reflow survival group were lower than those in control group （0.38 ± 0.11 vs 0.49 ± 0.10, P 〈 0.05 ）. 3-month mortality rate were 6.3 % and 0% in no-reflow survival group and the control group respectively. （2） 6-month UCG data suggested that LVEF in no-reflow survival group were lower than those in the control group （0.39 ± 0. 12 vs 0.50 ± 0. 11 ,P 〈 0. 05 ）. 6-month mortality rates were 12.5% and 2.2% in no-reflow survival group and the control group respectively. Conclusion Inpatients mortality rate , short and medium term mortality rate are higher in patients with no-reflow after emergency PCI and heart function is poorer in noreflow survival group than those of the control group. These results suggest that prevention of no-reflow in emergency PCI is an urgent issue.
作者 王健 颜红兵 朱小玲 高海 李南 艾辉
机构地区 首都医科大学附属北京安贞医院抢救中心
出处 《中国综合临床》 北大核心 2007年第8期716-718,共3页 Clinical Medicine of China
关键词 急性心肌梗死 直接PCI 无复流 左心室射血分数 病死率 Acute myocardial infarction Emergency PCI No-reflow Left ventricular ejection fraction Mortality rate
分类号 R542.22 [医药卫生—心血管疾病]
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参考文献7

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同被引文献29

  • 1刘方,廉哲勋,王永彬,葛毅萍.缺血后处理、ATP后处理减轻兔缺血再灌注损伤:与腺苷受体激活有关[J].现代生物医学进展,2007,7(3):353-355. 被引量：6
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  • 7Argaud L,Gateau-Roesch O,Raisky O,et al.Postconditioning inhibits mitochondrial permeability transition[J].Circulation,2005,111 (2):194-197.
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中国综合临床
2007年 第8期

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