摘要
本文采用微核试验方法对维生素Ｅ（ＶｉｔＥ）拮抗氯化汞（ＨｇＣｌ２）致小鼠胸骨骨髓多染红细胞微核作用进行了研究。其主要结果有：（１）给小鼠ＶｉｔＥ５ｍｇ／ｋｇ体重及以上剂量时，可显著地降低ＨｇＣｌ２１．０ｍｇ／ｋｇ体重的致小鼠微核作用（Ｐ＜０．００１）；（２）在ＨｇＣｌ２（１．０ｍｇ／ｋｇ）给小鼠染毒前４ｈ和染毒后２ｈ内补充ＶｉｔＥ２０ｍｇ／ｋｇ体重时，均显示明显地拮抗致微核作用（Ｐ＜０．００１～Ｐ＜０．０１）；（３）隔日给小鼠ＶｉｔＥ２．５ｍｇ／ｋｇ体重一个月后也可显著地减少ＨｇＣｌ２（１．０ｍｇ／ｋｇ）的致微核作用（Ｐ＜０．００１）。
In this paper,antagonistic effects of vitamin E(Vit E) on the rate of micronuclei in the mice bone marrow polychromatic erythrocyte induced by mercuric chloride(HgCl 2) was studied.The micronucleus test method was used.The results are as follows:(1)The rate of micronuclei induced by the combing Vit E 5mg/kg body weight or more plus HgCl 2 1.0mg/kg body weight was much lower than that of HgCl 2 control group(P<0.001);(2)When the experimental group mice recieved Vit E 20mg/kg body weight four hours before with HgCl 2 1.0mg/kg body weight,the rate of micronuclei was lower than that of HgCl 2 control group(P<0.001￣P<0.002);(3)The antagonistic effect of Vit E on HgCl 2-induced micronuclei was observed two hours after the mice treatment with HgCl 2 1.0mg/kg body weight(P<0.001￣P<0.01);and (4)The antagonistic effect of micronuclei caused by HgCl 2 1.0mg/kg body weight was also abviously after the mice were given Vit E 2.5mg/kgb body weight every two days for a month(P<0.001).
出处
《癌变．畸变．突变》
CAS
CSCD
1997年第3期168-171,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
维生素E
氯化汞
微核试验
小鼠
Vitamin E
Mercuric chloride
Micronucleus test
Mice
