摘要
目的探讨在肾移植患者中检测血清胱抑素C(serum cystatin C,SCysC)浓度评估肾小球滤过率(GFR)的可行性和临床应用价值。方法对39例初次肾移植患者采用颗粒增强透射免疫比浊法(PETIA)分别检测术晨、术后1、4周的SCysC,同时测定血清肌酐(Scr)、肌酐清除率(Ccr)等,并进行比较分析。结果患者术后随移植肾功能的恢复,SCysC较术前明显降低(P<0.01)。移植术前与术后不同时期,患者的SCysC与Scr、Ccr都具有良好的相关性;当50≤Ccr<80mL/min/1.73m2时,SCysC与Ccr的相关性明显优于Scr与Ccr的相关性,两者的相关系数分别为-0.778与-0.535。SCysC与Scr的ROC曲线下面积分别为0.964与0.915(P<0.01)。结论采用PETIA法检测SCysC具有敏感性、特异性高、方便、快捷、成本较低和可与其他生化指标同时检测等优点,因此SCysC可以作为一种理想的肾移植患者的GFR标志物应用于临床。
[Objective] To evaluate the feasibility and clinical value of serum cystatin C （SCysC） in assessing glomerular filtration rate in renal transplant patients. [Methods] Thirty-nine renal transplant patients （22 male/17 female） were recruited in the study. SCysC and serum creatinine （Scr） were determined before surgery, 1 week and 4 weeks after surgery, respectively. SCysC was determined by particle-enhanced turbidimetric immunopssay （PETIA）. The creatinine clearance （Ccr） was calculated followed the Cockcroft-Gault formula. [Results] SCysC and Scr levels significantly decreased with the recovery of allograft function. SCysC showed signiticant correlation w/th Scr and Ccr. At a Ccr level of 50-80 mL/min/1.73 m^2, the correlation between SCysC and Ccr （r =-0.778） was significantly better than that between Scr and Ccr （r =-0.553） （P =0.032）. The area under the curve （AUC） of ROC for SCysC and Scr are 0.964 and 0.915, respectively （P 〈0.05）. [Conclusions] SCysC is more sensitive to detect early and moderate deterioration of GFR compared to Scr in adult renal transplant patients.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第11期1352-1355,共4页
China Journal of Modern Medicine
关键词
血清胱抑素C
肾移植
肾小球滤过率
内生肌酐清除率
cystatin C
renal transplantation
glomerular filtration rate
creatinine
creatinine clearance
