摘要
呼吸机引起的横膈功能障碍是由机械通气后膈肌张力负荷下降、神经刺激减少、肌肉萎缩、结构损伤和肌纤维重塑等多因素引起的横膈肌收缩能力不全的临床现象，主要表现为脱机困难。机械通气时间、通气模式和潮气量等对呼吸机引起的横膈功能障碍的发生有显著影响。通过治疗原发病、合理通气、刺激膈神经和抗氧化干预等方法可以对其进行有效防治。
Ventilator-induced diaphragmatic dysfunction （VIDD） is an important clinical phenomenon characteristic of weaning failure. Such factors are involved in the etiopathogenisis as diaphragmatic tension declines,disuse muscle atrophy, muscular structure damage and diaphragm muscle remodeling. Ventilatory duration,ventilatory mode and tidal volume also attribute to the development of VIDD. It can be prevented or delayed by the treatment of primary diseases, rational ventilation,stimulation of phrenic nerve or antioxidants therapy.
出处
《国际呼吸杂志》
2007年第12期952-955,共4页
International Journal of Respiration
关键词
机械通气
膈肌萎缩
横膈肌功能障碍
Mechanical ventilation
Diaphragmatic muscle atrophy
Diaphragmatic dysfunction
