4Nestl B M,Glueck S M,Hall M,et al.Eur J Org Chem[J],2006,(20):4573-4577.
5Blicke F F,Faust J A.J Am Chem Soc[J],1954,76 (12):3157-3159.
6Hrometz S L,Shields K M.Role of ambrisentan in the management of pulmonary hypertension[J].Ann Pharmacother,2008,42(11):1563-1659.
7Cheng J W.Ambrisentan for the management of pulmonary arterial hypertension[J].Clin Ther,2008,30(5):825-833.
8Riechers H,ALbrecht H P,Amberg W,et al.Discovery and optimization of a novel class of orally active nonpeptidic endothelin——A receptor antagonists[J].J Med Chem,1996,39(11):2123-2128.
9Riechers H,Klinge D,Amberg W,et al.New carboxylic acid derivatives,their preparation and their use:EP,0785926[P].2001-08-22.
10Jansen R,Knopp M,Amberg W,et al.Structural similarity and its surprises:endothelin receptor antagonists-process research and development report[J].Org Process Res Dev,2001,5(1):16-22.
