摘要
报告1例多中心网状组织细胞增多症并发肝脏肿瘤。患者男,61岁。面部、胸部和上肢红斑4个月,伴关节肿痛、低热1个月就诊。皮损组织病理检查示真皮内有单核、双核及多核胞质丰富的组织细胞,胞质呈毛玻璃状,细胞核呈圆形,有明显的核仁位于核中央。免疫组化染色结果示lyso(+),CD68(+),Vim(+),S-100(-),CD1α(-)。患者有乙肝病史,甲胎蛋白(AFP)6820μg/L,腹部B超示肝脏右叶实质性占位,考虑恶性肿瘤可能。
We report a case of multicentric reticulohistiocytosis （MRH） with liver tumor. A 61-year-old man had lesions on the skin of his face,chest and limbs for four months and developed joint swelling, pain and fever for one month. Histopathologic examination showed dermal infiltrates composed of histiocytes which showed single-,double- or multi-nucleated giant cells with ground-glass cytoplasm and lymphocytes. Immunohistochemistry proved the positive staining for CD68 and negativity for CDla and S100 protein. The patient had a history of Hepatitis B and higher level of AFP （6820μg/L）. B ultrasonic scan showed a solid, possible malignant mass in the right lobe of liver.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2007年第7期447-449,共3页
Journal of Clinical Dermatology
