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加味温胆汤含药脑脊液抗Aβ细胞毒性作用及其机制的实验研究 被引量:4

Cerebrospinal Fluid Containing Modified Wendan Decoction for Protection Against β-amyloid_(25~35)-induced Injury in NG108-15 Cells
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摘要 目的:采用脑脊液药理学的方法探讨加味温胆汤治疗AD的作用机制。方法:运用体外细胞培养的方法,观察加味温胆汤含药脑脊液对Aβ25~35诱导的NG108-15细胞损伤的影响。结果:模型组p-JNK和p53的表达均增高,经治疗后均显著降低(P〈0.01),细胞被阻滞在S期。结论:加味温胆汤含药脑脊液神经保护作用与下调p-JNK和p53的水平有关。 Objective: To explore the effective mechanism of Modified Wendan Decoction in treating AD with "Cerebrospinal Fluid Pharmacology". Methods: NG108-15 cells were cultured in vitro detecting the action of Modified Wendan Decoction for protection against Aβ25-35-induced injury in NG108-15 cells. Results: Both of p-JNK and p53 are obviously up-regulated in the model group and both are dose-dependently down-regulated after treated( P 〈 0.01 ). The cells are arrested in S phase. Conclusion: The JNK signal pathway involved in the cell apoptosis process induced by the Aβ25-35 fragment, Cerebrospinal fluid containing Modified Wendan Decoction can down-regulate the level of p-JNK and p53,promote cells transfering from S phase to G2 phase. It can neutrolize the cytotoxicity to some degree. Its possible mechanism maybe relevant to the activation of JNK signal pathway and down-regulation of p53.
出处 《中国实验方剂学杂志》 CAS 2007年第7期26-28,共3页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家中医药管理局项目(04-05JP41)
关键词 加味温胆汤 脑脊液 阿尔茨海默病 信号转导 Modified Wendan Decoction cerebrospinal fluid alzheimer's disease signal pathway
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