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益母草碱对大鼠急性心肌缺血损伤心肌肌钙蛋白T的影响 被引量:18

Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats
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摘要 目的:观察益母草碱(Leo)对大鼠急性心肌缺血损伤心肌肌钙蛋白T(cTnT)水平的保护作用。方法:采用垂体后叶素(Pit)腹腔注射法诱导大鼠急性心肌缺血,以J点(Δmv)和T波(Δmv)上移幅度评价急性心肌缺血程度;采用放免法检测血清及心肌cTnT的含量。结果:益母草碱(3,5,7,9 mg/kg)可防止Pit诱导急性心肌缺血J点及T波的抬高,并能降低血清和心肌cTnT含量(P<0.05或P<0.01),在一定剂量范围内存在量效关系。结论:Leo具有对抗垂体后叶素性急性心肌缺血损伤的作用。 Objective: To investigate the protective effect of leonurine (Leo) on pituitrin (Pit)-induced acute myocardial ischemia injury in rats. Methods: Pit was administrated intraperitoneally to induce acute myocardial ischemia injury in rats. The locomotion of J point(mv) and T wave (mv) in ECG was allowed to evaluate the degree of myocardial ischemia. The content of cardiac troponin T (cTnT) in serum and myocardium was measured by radio immunoassay. Results:In Leo(3,5,7,9 mg/kg) groups, the elevation of J point and T wave was lowered. The contents of cTnT in serum and myocardium were obviously decreased. Linear regression analysis (scatterplot) indicated that there is dose-effect relationship within certain dose range. Conclusions: Leo can inhibit Pit-induced myocardial ischemia injury, with dosedependent effect.
作者 熊莺 杨解人
出处 《中国实验方剂学杂志》 CAS 2007年第2期21-24,共4页 Chinese Journal of Experimental Traditional Medical Formulae
基金 安徽省教育厅自然科学基金项目(2003kj322)
关键词 益母草碱 垂体后叶素 心肌缺血 心肌肌钙蛋白T Leonurine Pituitrin Myocardial ischemia Cardiac troponin T
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参考文献4

  • 1Chen CX, K wan CY. Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort [J]. Life Sci.2001 ;68(8) :953-960.
  • 2周远鹏,刘文化,邵国贤.益母草碱、丁香酰胍醇及丁香酸氨基醇酯类化合物抗血小板聚集活性及其与结构的关系[J].中国药学杂志,1996,31(5):271-274. 被引量:18
  • 3Goktekin O, Melek M, Gorenek B, et al. Cardiac troponin T and cardiac enzymes after external transthoracic cardioversion of ventricular arrhythmias in patients with coronary artery disease [J]. Chest. 2002 ; 122 (6) : 2050-2054.
  • 4Zaricha S, Qamar A, Werdmann M, et al. Value of a single troponin T at the time of presentation as compared to serial CK-MB determinations in patients with suspected myocardial ischemia [J]. Clinica Chimica Acta. 2002 ; 326 : 185-192.

二级参考文献4

  • 1团体著者,中药大辞典.下,1986年
  • 2莫若莹,药学学报,1985年,20卷,8期,584页
  • 3邵国贤,药学学报,1984年,19卷,6期,419页
  • 4尹钟洙,新药学杂志,1977年,12期,37页

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