摘要
为研究抗凋零基因bcL-2在胆囊癌组织中的表达,收集我院经病理确诊的42例胆囊癌标本和12例性性胆囊炎标本,采用免疫组化染色,探讨抗凋零基因bcL-2在胆囊癌组织中的表达。结果显示42例胆囊癌组织中,bcL-2阳性者24例(占57%),表现为肿瘤细胞胞浆内呈棕黄色细颗粒,而12例胆囊炎标本中,仅1例呈弱阳性,两组比较P<0.01。结果提示:胆囊癌组织中抗凋零基困bcL-2具有高表达。本研究为进一步根据胆囊癌细胞凋零特点,通过改变其凋零表型治疗胆囊癌提供了理论依据。
This study observed the bCL-2 as a tu- mour gene in patient with gallbladder carcinoma. A restrospective study 42 patients with gallbledder carcinoma and 12 paients with chornic cholecystitis tissue as con- trol . was carriedout on the bCL-2 gene expression by S- P immunohistochemistry assay. Immunohistochemical stain shows that 24 out of 42 patients with gallbladder carcinoma positive. The sildes show that bCL-2 gene are stained with brownish granules , mainly located in the cytoplasm . The positive rate is 58. 9% . 1 out 12 paients with chronic cholecystitis shows positive. There is signi- flcant difference in these two kinds of tissue. This study indicates that bCL-2 may play a significant role in the gallbladder carcinoma .
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1997年第2期73-74,共2页
Chinese Journal of Experimental Surgery