摘要
目的观察丙泊酚对全身炎症反应综合征(SIRS)患者前降钙素(PCT)的影响。方法将60例SIRS患者随机分为两组,丙泊酚组(n=30)和咪唑安定组(n=30),监测患者入院当天及入院后3、5、7d的体温、血常规以及外周血中PCT水平,记录患者的急性生理和慢性健康状况评分(APACHEⅡ),并追踪患者的转归。结果丙泊酚组除入院当天外,其余各个时点的PCT水平均明显低于咪唑安定组(p<0.05),两组的PCT水平都呈下降趋势,丙泊酚组经治疗第3d后的PCT水平与入院时相比均明显降低(p<0.05),而咪唑安定组经治疗第3d后的PCT水平与入院时相比,无显著性差异。两组患者APACHEⅡ评分、白细胞计数、中性粒细胞比例、体温以及死亡率均无显著性差异。结论丙泊酚可有效降低SIRS患者外周血中PCT水平。
Objective To observe the effects on procalcitonin in SIRS patients sedated with propofol. Methods 60 SIRS patients were randomly divided into propofol group（ n = 30）and mizodam group（ n = 30）. All the patients received the continuous monitoring including body temperature, blood routine and the level of procalcitonin is serum. They were also recorded the APACHE Ⅱ score and the prognosis. Results The procalcitonin level in propofol group were dramatically lower than those in mizodam group on every time point excluding in the in - hospital time. The procalcitonin level in two groups tended to decrease day by day, but the procalcitonin level after 3 days treatment in propofol group were markedly lower than that in the first day ： There were no difference between two groups in term of APACHE Ⅱ score, white cell count, proportion of neutrophil, body temperature and mortality. Conclusion Propofol could decrease the procalcitonin level in serum effectively.
出处
《现代医院》
2007年第7期25-26,共2页
Modern Hospitals
