摘要
近年，在表型及基因型水平上均发现存在药物氧化代谢多态性，特别是对于人类细胞色素Ｐ４５０氧化酶与药物氧化代谢遗传多态性的关系进行了深入的研究。有关ＣＹＰ２Ｄ６、ＣＹＰ２Ｃ１９等的突变已大多被鉴定；ＣＹＰ１Ａ１、ＣＹＰ１Ａ２等在表型存在多态性而确切的遗传机制尚不清楚。另有一些Ｐ４５０酶（如ＣＹＰ２Ａ６、ＣＹＰ２Ｃ９、ＣＹＰ２Ｅ１、ＣＹＰ３Ａ４等），在表型或基因型水平似乎存在多态性，但尚未有确切依据。本文对这些Ｐ４５０酶多态性的分子机制作了详细综述。
Polymorphism has been detected in a variety of drug metabolizing enzymes at both phenotypic and genotypic level. Human cytochrome P450 enzymes have been studied extensively in recent years, and the majority of mutations which give rise to a defective phenotype have now been identified(for example CYP2D6, CYP2C19, etc.). There are some groups of enzymes showing definite polymorphism at the phenotypic level but the exact genetic mechanisms are not yet clear(CYP1A1, CYP1A2, etc.). There are still other groups of enzymes, showing some indication of polymorphism at either the phenotypic or genotypic level yet have not been unambiguously demonstrated(for example CYP2A6, CYP2C9, CYP2E1, CYP3A4, etc.). The molecular mechanism of all these polymorphisms and possible polymorphisms is discussed, with paticular reference to the effects of this variation on drug metabolism and on the susceptibility to chemically induced diseases.
出处
《生理科学进展》
CAS
CSCD
北大核心
1997年第1期35-40,共6页
Progress in Physiological Sciences
