摘要
目的探讨高血压合并心房颤动(简称房颤)患者血小板和内皮细胞功能的变化。方法选择轻、中度原发性高血压患者110例,其中伴房颤60例为房颤组,无房颤50例为对照组。测定两组血浆P-选择素、内皮素-1(ET-1)及血管性血友病因子(vWF)水平。结果房颤组血浆P-选择素、ET-1及vWF水平与对照组比较差异有统计学意义(P<0.01)。结论高血压合并房颤患者存在有血小板活性增高及内皮功能受损,临床工作中应重视内皮细胞功能的改善和血小板的抗凝治疗。
[ObjectiveS] To investigate the effects of atrial fibrillation complicated with hypertension on function of endothelial cells and platelet cells. [Methods] One hundred and ten patients with mild to moderate essential hypertension were enrolled. Sixty of them were complicated with atrial fibrillation. Patients were classified into two groups： atrial fibrillation accompanied by hypertension and only hypertension group. Plasma P-selectin, endothelin-1 （ET-1） and von willebrand factor（vWF） were measured. [Results] Plasma concentrations of P-selectin, vWF and ET-1 in atrial fibrillation group were significantly higher than those in the control group. [Con clusion] Dysfunction of endothelial cells and platelet cells were found in atrial fibrillation with hypertension patients. More attention should be paid to the improvement of the endothelial and platelet.
出处
《山东医药》
CAS
北大核心
2007年第7期3-4,共2页
Shandong Medical Journal
关键词
心房颤动
高血压
内皮素
P-选择素
血友病因子
atrial fibrillation
hypertension
endothelin
P-selecin
yon willebrand factor
