摘要
目的:观察血清胸腺因子(FTS)对人肝癌细胞的抑制作用。方法:裸鼠皮下接种人肝癌细胞 Hepg-2,待肿瘤生长后连续皮下注射不同剂量的 FTS,测定其抑瘤率;并测定 T 细胞增殖能力、吞噬指数(PI)等免疫指标。结果:荷瘤裸鼠皮下注射高、中剂量后抑瘤率均大于30%,且与对照组(NS)有显著性差异(p<0.01),低剂量组与 NS 组无显著性差异。另外 ConA 刺激后0.016 mg·mL^(-1)处刺激指数(SI)最大,FTS 组 PI 明显大于 NS 组。结论:FIS 对人肝癌细胞 Hepg-2有抑瘤作用且增强其免疫功能。
Objective: To study the inhibitory effect of serum thymic factor (FTS) on cancer cells. Method: Bearing cancer nude mice were administrated FTS. Inhibitory rate were determined. Stimulation index (SI) and phagocytic index (PI) were determined,too. Results :Inhibitory rate exceeded 30% in high dose group and middle dose group in nude mice. After ConA stimulated, SI achieved maximum at 0. 016 mg· mL^-1. PI were about 2 times as much as the control. Conclusion: FTS shows significant suppressing action on the growth of human liver cancer cells and it enhances the immunology activity of the organism.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2007年第6期860-862,共3页
Chinese Journal of Pharmaceutical Analysis
关键词
血清胸腺因子(FTS)
肝癌细胞
抑瘤作用
免疫增强
serum thymic factor(FTS)
human liver cancer cells
inhibitory effect
immundogical enhancement