摘要
目的:研究格尔德霉素在溶液状态下的光解动力学特征。方法:以白炽灯作为光源进行照射,用 RP-HPLC 法监测格尔德霉素残留浓度,绘制光解动力学曲线,分别按零级、一级和二级反应方程进行拟合并获得相应参数。结果:格尔德霉素光解动力学总体反应符合一级反应方程。结论:格尔德霉素在光照条件下不稳定,且随着光照强度的增加和浓度的降低,光解速度加快,半衰期(t_(1/2))缩短。
Objective ： To investigate the photodegradation kinetic characters of geldanamycin solution. Method： RP -HPLC method was used to determine the residual concentration of geldanamycin solution which was exposed to the lamp ; curves of photodegradation kinetics were drawn, and the order of reaction and parameters were also measured. Result：The photodegradation of geldanamycin followed the first - order kinetics. Conclusion：It is found that geldanamycin is sensitive to the light, the rate of photodegradation is faster and ill2 shorter with the increase of light intensity and the decrease of concentration.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2007年第6期867-869,共3页
Chinese Journal of Pharmaceutical Analysis
