摘要
用二乙基亚硝胺(DEN)致大鼠肝癌前病变实验模型,研究从鲜柑皮提取的挥发性柑皮油对致癌作用的影响。于大鼠接受 DEN 前10天起,饲以含5%柑皮油饲料。经两次重复实验,结果均显示:肝癌前病变 Gam-ma-谷氨酰转肽酶阳性肝细胞增生灶(GGT 灶)的发生数(个/cm^2),用柑皮油组明显少于单给 DEN 的对照组(P<0.05～0.01),对 GGT 灶数的抑制率可达44.0%;灶面积(mm^2/cm^2)也小于对照组(P<0.05),对灶增长的抑制率可达55.73%。表明柑皮油有抑制 DEN 致大鼠肝癌前病变发生发展的作用。
5% citrus peel oil (CPO) containing diet was fed to the rats 10 days prior one dose of diethylnitrosamine (DEN,i.p.)to 3-7 days after DEN exposure.The occurrence of precancerous le- sions of the liver induced by DEN was inhibited.The liver cell precancerous hyperplastic foci positive for gamma-glutalmyltranspeptidase (GGT foci) in the rats treated with CPO was much less and smaller than those exposed to DEN alone (P<0.05).The inhibition rate in the number of GGT foci (No./ cm^2) may reach 44.0 % and in the area of GGT foci (mm^2/cm^2) may reach 55.73 %.These results sug- gest that CPO possesses the inhibitory effect on DEN hepatocarcinogenesis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1997年第1期22-25,共4页
Chinese Journal of Cancer
基金
卫生部科研基金资助
关键词
二乙基亚硝胺
柑皮油
肝肿瘤
癌前病变
Diethylnitrosamine
Citrus peel oil
Hepatocarcinogenesis Precancerous lesion
Chemoprevention
