摘要
目的:对精神药物的治疗药物监测(TDM)现状进行了总结分析,以指导临床合理用药。方法:结合国内外相关文献,从TDM的历史、临床意义、测定方法、药物与TDM的关系、成本效益分析等方面进行了评价。结果:一些精神药物如氟哌啶醇、氟奋乃静、碳酸锂、多塞平、米帕明、地昔帕明、去甲替林、氯氮平的药效关系及治疗窗已经确定,临床中应进行TDM。奥氮平和利培酮在临床中推荐使用TDM。结论:精神药物的TDM对临床有积极的意义,但临床实施尚有待加强,随着药动学-药效学等的发展,更多的精神药物的TDM将被证实。
OBJECTIVE： To analyze the status quo of the therapeutic drug monitoring （TDM） of psychotropic drugs so as to provide a guide for the rational use of these drugs. METHODS： Based on the related literature at home and abroad, an evaluation was performed in terms of the history, clinical significance and determination method of TDM, the relationship between TDM and drugs and cost -effectiveness etc. RESULTS： Some psychotropie drugs, such as haloperidol, fluphenazine, lithium carbonate, doxepin, imipramine, desipramine, nortriptyline and clozapine had definite concentration- effect relationship and therapeutic window, therefore, TDM of these drugs should be performed in their clinical application. It is recommended to perform TDM in the clinical use of olanzapine and risperidone. CONCLUSION： It is of great importance to perform TDM of psychotropic drugs, but its practice in the clinic is remained to be strengthened. With the development of pharmacokinetics - pharmacodynamics, the TDM of more psychotropic drugs would be realized.
出处
《中国医院用药评价与分析》
2007年第3期176-179,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
治疗药物监测
精神药物
血药浓度
临床效应
合理用药
Therapeutic drug monitoring （TDM）
Psychotropic drugs
Blood concentration
Clinical effect
Rational use of Drugs
