摘要
多脂鳞伞[Pholiota adiposa(Fr.)Quel.]菌丝体多糖溶液给S-180荷瘤小鼠连续灌胃10d后,测定对荷瘤小鼠抑瘤率、碳粒廓清指数、小鼠外周血肿瘤坏死因子(TNF-α)和白介素-2(IL-2)含量的影响。结果发现,多脂鳞伞菌丝体多糖对荷瘤小鼠肿瘤的抑瘤率为39.54%,并可提高小鼠碳粒廓清指数,血清中IL-2和TNF-α的含量也明显提高。结果提示,多脂鳞伞菌丝体多糖抑制荷瘤小鼠的肿瘤生长可能与增强宿主的免疫功能相关。
Treatment of S-180 tumor-bearing mice with polysaccharide extracted from Pholiota adiposa mycelium resulted in lower tumor weights, increased carbon particle clearance and phagocytic indices, and significantly higher serum levels of TNF-α and IL-2, compared with untreated controls. Our data suggest that the anti-tumor activity of P. adiposa polysaccharide is related to immuno-enhancing activity.
出处
《食用菌学报》
2007年第2期49-54,共6页
Acta Edulis Fungi
关键词
碳粒廓清指数
白介素-2
肿瘤坏死因子-Α
多脂鳞伞
多糖
Carbon particle clearance index
Interleukin-2
Pholiota adiposa
Polysaccharide
Tumor necrosis factor-alpha
