摘要
目的探讨经皮自体骨髓间充质干细胞(MSCs)移植治疗四肢骨折骨不连的临床疗效。方法1999年5月-2006年5月,对48例四肢骨干骨折骨不连患者采用经皮注射MSCs进行治疗。结果48例患者获3~48个月(平均12.6个月)随访,42例患者达到骨性愈合,骨折愈合时间(注射MSCs的时间)为4.7个月(3~6个月),X线显示骨折线消失和骨痂形成。结论经皮自体MSCs移植术是一种治疗四肢骨干骨不连的有效和安全的方法,具有临床应用价值。
Objective To explore the effect of transplatation of percutaneous autologous mesenchymal stem cells (MSCs) on treatment of bone nonunion. Methods From May 1997 to May 2003, 48 cases with bone nonunion were treated by BMCs . Results All 48 cases were followed up for 3-48 months(average 12.6 months). Average cured time of 4.7 months (3-6 months) in 42 cases of bone nonunion, X-ray displayed disappearance of fractional line and formation of continuous callus. Conclusion MSCs transplation plays a main role in osteogenesis at the site of bone nonunion, the effect is satisfactory, it has clinical application value.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2007年第7期499-501,共3页
Chinese Journal of Trauma
关键词
移植
自体
骨髓基质干细胞
骨折
四肢
骨不连
Transplantation, autogenous
Mesenchymal stem cells
Fractures, Extremities
Bone nonunion