期刊文献+

经皮自体骨髓间充质干细胞移植治疗四肢骨折骨不连 被引量:25

Transplantation of percutaneous autologous mesenchymai stem cells for treatment of ununion of extremity fractures
原文传递
导出
摘要 目的探讨经皮自体骨髓间充质干细胞(MSCs)移植治疗四肢骨折骨不连的临床疗效。方法1999年5月-2006年5月,对48例四肢骨干骨折骨不连患者采用经皮注射MSCs进行治疗。结果48例患者获3~48个月(平均12.6个月)随访,42例患者达到骨性愈合,骨折愈合时间(注射MSCs的时间)为4.7个月(3~6个月),X线显示骨折线消失和骨痂形成。结论经皮自体MSCs移植术是一种治疗四肢骨干骨不连的有效和安全的方法,具有临床应用价值。 Objective To explore the effect of transplatation of percutaneous autologous mesenchymal stem cells (MSCs) on treatment of bone nonunion. Methods From May 1997 to May 2003, 48 cases with bone nonunion were treated by BMCs . Results All 48 cases were followed up for 3-48 months(average 12.6 months). Average cured time of 4.7 months (3-6 months) in 42 cases of bone nonunion, X-ray displayed disappearance of fractional line and formation of continuous callus. Conclusion MSCs transplation plays a main role in osteogenesis at the site of bone nonunion, the effect is satisfactory, it has clinical application value.
出处 《中华创伤杂志》 CAS CSCD 北大核心 2007年第7期499-501,共3页 Chinese Journal of Trauma
关键词 移植 自体 骨髓基质干细胞 骨折 四肢 骨不连 Transplantation, autogenous Mesenchymal stem cells Fractures, Extremities Bone nonunion
  • 相关文献

参考文献10

  • 1梁雨田,张伯勋,卢世璧,陶笙,肖嵩华.经皮自体骨髓移植治疗骨折不愈合[J].中华骨科杂志,1999,19(12):709-711. 被引量:97
  • 2Prockop DJ,Marrow stromal cells as stem cells for nonhematoopoietic tissues.Science,1997,76:71-74.
  • 3Pittenger MF,Mackay AM,Beck SC.Multilineage potential of adult human mesenchymal stem cells.Science,1999,284:143-147.
  • 4Shi XM,Blair HC,Yang X,et al.Tandem repeat of C/EBP binding sites mediates PPAR gamma 2 gene transcription inglucocorticoid-induced adipocyte differentiation.J Cell Biochem,2000,76:518-527.
  • 5Hernigou A,Poignard F,Beanjean H,et al.Percutaneous autologous bone-marrow grafting for nonunions.J Bone Joint Surg(Am),2005,87:1430-37.
  • 6Soltan M,Smiler DG,Gailani F,A new“platinum”standard for bone grafting:autogenous stem cells.Implant Dent,2005,14:322-325.
  • 7Connolly JF,Guse R,Tiedeman J,et al.Autologous marrow injection as a substitnte for operative grafting of tibial nonunions.Clin Orthop,1991,(266):259-270.
  • 8Healey JH,Zimmerman PA,McDonnell JM,et al.Percutaneous bone marrow grafting of delayed union and nonunion in cancer patients.Clin Orthop,1990,(256):280-285.
  • 9Johnson KD.Management of malunion and nonunion of the tibia.Orthop Clin North Am,1978,18:157-171.
  • 10Knop I,Sitte F,Canto M,et al.Successful posterior interlaminar fusion at the thoracic spine by sole use of β-tricalcium phosphate.Arch Orthop Trauma Surg,2006,126:204-210.

二级参考文献6

共引文献96

同被引文献309

引证文献25

二级引证文献118

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部