摘要
造血干细胞移植治疗成人急性白血病5例，包括3例第一次完全缓解（CR1）急性粒细胞白血病，1例CR1急性淋巴细胞自血病，1例急性粒细胞白血病复发。其中异基因骨髓移植（alloBMT）4例，同基因外周血造血干细胞移植（Syn－PBSCT）1例。所有病例均采用TBI＋CY＋CCNU作预处理。所有病例均移植成功。2例发生急性移植物抗宿主病（aGVHD），其中1例又发生慢性GVHD。1例未缓解患者移植后完全缓解，但于+69天死于间质性肺炎；3例已分别无病生存22、10和3个月；余1例（急淋）移植后12个月死于复发。结果尚提示外周血干细胞移植造血重建更快。
5 Patients with adult acute leukemia were treated with hematopoietic stein cell transplantation,including 3 cases with AML in CR1,a case with ALL in CR1,a case with AML relapse in NR. Among them 4 patients were treated with allogeneic bone marrow transplantation (allo-BMT), a patient with syngeneic peripheral blood stem cell transplantation (Syn-PBSCT). All patients were conditioned by TBI +CY +CCNU. The hemopoietic function of all patients was recovered and had confirmed engraftment. Two cases presented aGVHD,one of them also presented cGVHD. One case who was in NR achieved CR after the BMT,but the patient died from severe interstitial pneumonia in day + 69; Three patients are leukemia free survivors for 22、10 and 3 months;one case (ALL) died from relapse in 12 months post-BMT. The result also indicated that the patient with PBSCT had a quicker hematopoietic reconstitution.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第4期294-297,共4页
Chinese Journal of Clinical Oncology
