摘要
为了揭示胆道流体力学和心血管功能相互关系,以及从静脉输注胆囊收缩素八肽(Cholecys-tokinin,CCK-OP)、血管活性肠肽(Vasoactive intestinal peptide,VIP)和P物质(Substance P,SP)等胃肠道神经肽对它们相互关系的影响,作者观察了91只豚鼠在静脉输注CCK-OP、VIP、SP及CCK-OP和VIP同时输注时左心室活动,Oddi括约肌活动和胆总管内压力的变化。观察结果:静注CCK-OP能明显促使胆总管内压升高,Oddi括约肌活动增强,并使Oddi括约肌基础压力降低;CCK-OP同时引起左心室活动减弱。VIP单独输注时对胆道Oddi括约肌活动和左心室活动并无明显影响;但在与CCK-OP共同输注时可拮抗CCK-OP在这两方面的作用。输注SP对胆道Oddi括约肌和心血管的作用与CCK-OP相似,但作用强度不及CCK-OP。实验表明,胆道Oddi括约肌的活动和心血管功能有着密切的相互关系;胃肠道神经肽在它们相互影响中起着重要作用。
We tested in vivo: (a)the effect of an Ⅳ infusion of cholecystokinin octapeptide, vasoactive intestinal peptide or substance P on dynamics of biliary system and cardiovascular system, (b) the relation of dynamics of biliary system and cardiovascular system. In 91 anesthetized guinea pigs, left ventricle motility of heart, sphincter of Oddi motility and common bile duct pressure were monitored during the intravenous administration of cholecystokinin octapeptide(CCK-OP), vasoactive intestinal peptide(VIP), substance P(SP) and combination of CCK-OP and VIP. Intravenous CCK-OP increased fasting Oddis sphincter motility index, decreased the basal pressure in sphincter of Oddi, increased common bile duct pressure, and decreased the left ventricle of heart motility. VIP alone showed no significant effect on biliary system and cardiovascular system, but in conjunction with CCK-OP it produced inhibition on the effects of CCK-OP on both sides. Exogenous SP acted like CCK-OP on both biliary system and cardiovascular system, but it was less potent. We conclude that it may be an important interaction between dynamics of biliary system and cardiovascular system; and gastrointestinal peptide plays an important role in this interaction in guinea pigs.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1997年第1期48-51,共4页
Chinese Journal of Surgery
基金
卫生部面上基金
湖北省自然科学基金
