摘要
目的观察中药狼疮静颗粒对活动性狼疮性肾炎(LN)肾虚湿毒证的临床疗效。方法符合入组条件的LN患者共40例,治疗组22例(西药治疗加狼疮静颗粒),对照组18例(单纯西药治疗),疗程12周,观察治疗前后24h尿蛋白定量(Upr)、尿沉渣红细胞计数(URBC)、血尿素氮(Bun)、血肌酐(Scr)、SLEDAI积分及肾虚湿毒证主要证候的变化,以及治疗期间西药的副作用。结果治疗组对蛋白尿<3.5 g/24 h的患者在d 8以后减少蛋白尿的作用较好,减轻血尿、降低SLEDAI积分的作用于第4周即表现出明显的优势,组间比较有统计学意义(P<0.05),并对肾功能有一定的改善,同时治疗组较对照组能更好地缓解皮肤红斑、腰酸痛症状(P<0.05),减少激素所致的心悸、手抖等副作用(P<0.05)。结论在西药免疫抑制治疗的基础上配合使用中药狼疮静颗粒,有助于控制狼疮的病情活动、缓解临床症状、减少西药的副作用,对减少蛋白尿、减轻血尿、改善肾功能有较好的促进作用。
OBJECTIVE To observe the effect of the Chinese drug Langchuangjing Granule in the treatment of the syndrome of kidney deficiency with damp toxin in patients with active lupus nephritis（LN）. METHOD Forty LN patients were divided into a treatment group of 22 patients （treated with western medicine and Langchuangjing Granule） and a control group of 18 patients （treated with western medicine only） and were treated for 12 weeks. RESULT Good effect was obtained in relieving albuminuria in the patients with a level of 〈 3.5g/24 h after the 8th day, and hematuria and SLEDAI integral started to be reduced markedly since the 4th week, with statistical significance between the two groups （ P 〈 0.05 ）. Kidney function was improved. Better effect was obtained in the treatment group in relieving skin red patches, lumbago, palpitation caused by hormone and tremor of the hand （ P 〈 0.05）. CONCLUSION Based on the immunity inhibition treatment with western medicine, Langchuangjing Granule is effective in controlling the condition of LN, relieving the clinical symptoms, reducing the side effect of western medicines, relieving albuminuria and hematuria, and improving the kidney function.
出处
《南京中医药大学学报》
CAS
CSCD
2007年第4期220-223,共4页
Journal of Nanjing University of Traditional Chinese Medicine
关键词
狼疮静颗粒
狼疮性肾炎
中医药疗法
肾虚湿毒证
Langchuangjing Granule
lupus nephritis
TCM treatment
syndrome of kidney deficiency with damp toxin
