摘要
本文以苯甲醛和丙二酸为原料,吡啶等有机碱为催化剂,利用Knoevenagal反应合成肉桂酸,从而降低了反应温度,提高了产率和产品纯度,简化了合成工艺。同时,比较和分析了不同弱碱催化剂对肉桂酸合成产率的影响,结果表明吡啶的催化效果最好,并通过正交试验探讨了有机碱催化作用下,不同工艺参数对肉桂酸产率的影响,确定反应的最佳工艺条件为:以吡啶为催化剂,反应物苯甲醛/丙二酸摩尔比取1:3,催化剂用量0.02mol,反应时间为90min,肉桂酸产率可达90%。
Cinnamic acid was synthesized from benzaldehyde and malonic acid as the raw material, and the organic weak - base such as pyridine as the catalyst by Knoevenagel reaction. The main objective of this paper is to improve the synthetic technique of cinnamic acid, reduce the reaction temperature and enhance the yield and purity of the product. Meanwhile, the influence of various weak - base catalysts on yield of cinnamic acid was compared and analyzed. The results indicated that pyridine was the optimal catalyst. Furthermore, in the presence of the organic alkali catalyst, the effects of various technical parameters on the yield of products were investigated by using orthogonal design, and the optimum conditions found for synthesizing cinnamic acid were as follows： pyridine is the optimum catalyst and its amount is 0.02 mol, the molar ratio of benzaldehyde to malonic acid was 1 ： 3, the reaction time was 90min, and the yield reached 90% under these conditions.
出处
《化学工程师》
CAS
2007年第7期1-3,共3页
Chemical Engineer
基金
湖北省教育厅2006年度科研资助项目(D200618006)
