摘要
目的探讨安普贴联合金因肽(重组人表皮生长因子)治疗老年重度压疮患者的临床效果。方法将65例(94处)老年Ⅳ期压疮患者随机分为三组,均按相同方法清创后,观察组21例(31处)疮面敷盖安普贴,待长出肉芽后先喷洒金因肽,再敷盖安普贴;对照1组22例(32处)疮面单纯敷盖安普贴;对照2组22例(31处)疮面敷1%聚维酮碘液纱布,然后敷盖无菌纱布。均根据疮面情况按需换药,观察记录三组压疮疮面肉芽生长时间、疮面缩小直径、换药次数、治愈时间及治愈率。结果5项指标中除治愈率外,观察组均显著优于对照1、2组(P<0.05,P<0.01)。结论安普贴联合金因肽治疗老年患者重度压疮效果显著优于聚维酮碘换药和单纯安普贴换药。
Objective To investigate the effectiveness of Algoplaque combined with rhEGF treating severe bedsore in elderly patients. Methods Sixty-five elderly patients with severe bedsores were randomly divided into three groups： observation group （Algoplaque combined with rhEGF, 21 cases, 31 bedsores）, control group Ⅰ （Algoplaque alone, 22 cases, 32 bedsores） and control group Ⅱ （1% povidone iodine, 22 cases, 31 bedsores）. The time for wound surface granulation growth, the reduced size of decubital ulcer, frequency of dressing change, the healing time and healing rate were assessed. Results The time for wound surface granulation growth and the healing time was shorter, and the reduced size of decubital ulcer and frequency of dressing change was less in observation group than those in control group Ⅰ or Ⅱ （P〈0. 05, P〈0. 01）, but there was no significant difference in healing rate among them. Conclusion The clinical effectiveness of Algoplaque combined with rhEGF in treating severe bedsore in elderly patients was more satisfactory than povidone iodine and Algoplaque used alone.
基金
韶关市卫生局医药卫生计划项目(Y05077)
