摘要
目的对腋淋巴结阴性乳腺癌患者进行预后分析。方法选择２２个可能对腋淋巴结阴性乳腺癌患者预后产生影响的非重复特征性临床因素，通过计算机Ｃｏｘ多因素分析模型，利用累积生存率，对１４８４例手术切除的腋淋巴结阴性乳腺癌患者进行预后分析。结果在选取的２２个因素中，月经状况、妊娠次数、病期、合并妊娠或哺乳、肿瘤大小、内乳淋巴结、术后放疗、术后三苯氧胺辅助治疗是影响腋淋巴结阴性乳腺癌患者预后的独立预后因素（Ｐ＜０．０５）。结论用临床资料对腋淋巴结阴性乳腺癌患者进行预后分析，可发现部分高危人群。腋淋巴结阴性的乳腺癌患者术后不宜放疗或行卵巢切除，术后三苯氧胺辅助治疗不应仅局限于绝经后或雌激素受体阳性的患者。如何选择高危人群进行术后化疗，有待进一步研究。
Objective To study the prognosis of axillary node negative breast cancer patients. Methods The data were analyzed in 1 484 consecutive axillary node negative breast cancer patients. Twenty two individual variables were evaluated statistically using the cumulative survival rate by the computer's Cox multivariate analysis model. Results Menopausal status, times of pregnancy, duration before diagnosis, pregnancy associated, tumor size, intramammary lymph node, postoperative radiotherapy and postoperative adjuvant tamoxifen therapy were independent predictors of prognosis. Conclusion Parts of high risk group among axillary node negative breast cancer patients could be identified by clinical parameters. Postoperative radiotherapy or ovarian ablation was not indicated for axillary node negative breast cancer patients. Tamoxifen as postoperative adjuvant therapy should not be restricted to postmenopausal or ER positive patients. The selection of high risk patients with axillary node negative breast cancer who should receive adjuvant chemotherapy remains to be investigated at present.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1997年第3期221-224,共4页
Chinese Journal of Oncology
关键词
乳腺肿瘤
淋巴转移
模型
预后
Breast neoplasms Lymphatic metastasis Models, statistical Prognosis
