摘要
在大鼠自体血凝块颅内注入的脑血肿模型上 ,给予中风脑得平冲剂进行治疗。实验结果 :大鼠脑血肿形成后 ,脑组织Na+ 、Ca2 + 及H2 O的含量明显升高 ;脑血管通透性增强 ,脑内伊文斯蓝 (E vantsBlueEB)含量显著增加 ,且有随病程增加而逐渐增高之趋势。应用中风脑得平冲剂后 ,可明显减轻上述指标的异常升高 ,尤其在降低脑水、Na+ 含量方面作用更为显著 。
The experimental cerebral hematoma model was induced by injecting autogenous clot into rats. The influences of Zhongfeng Naodeping granules on cerebral index,the contents of water, Na +, K +,Ca 2+ and Mg 2+ of the brain tissue, and the cerebrovascular permeability, in 6 h, 12 h, 48 h, and 72 h after the induction of cerebral hematoma, were observed, and the results showed that in the model group, the cerebral index and the contents of water and Na + of the brain tissue had a progressive increase, and the cerebrovascular permeability, especially that of the right side of the brain (with hematoma) became evidently enhanced; Zhongfeng Naodeping granules could alleviate cerebral edema, and reduce cerebral index, the contents of water and Na + of the brain tissue, and lessen the cerebrovascular permeability. The results of the research suggest that Zhongfeng Naodeping granules are useful in the treatment of encephaledema induced by experimental cerebral hematoma.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
1997年第3期35-36,共2页
Journal of Beijing University of Traditional Chinese Medicine
基金
"八五"国家科技攻关课题
关键词
脑血肿
脑水肿
中风脑得平冲剂
Zhongfeng Naodeping Granules
Cerebral Hematoma
Cerebral Edema
Blood Brain Barrier
Rat
