摘要
目的:探讨葛根素(Puerarin,Pue)对异丙肾上腺素(Isoproterenol,Iso)所致大鼠心肌肥厚的相关细胞因子的影响。方法:40只SD大鼠随机分成正常对照组(空白组)、异丙肾上腺素组(Iso组)、葛根素组(Pue组)和卡托普利(Captoril,Cap)组(Cap组)各10只。通过皮下注射Iso制成心肌肥厚模型,以葛根素干预,卡托普利为对照,对4组大鼠行心室重量指数(VW/HW)、心肌细胞横径(TDM)、血液和组织中的内皮素(ET)、一氧化氮(NO)、血管紧张素Ⅱ(AngⅡ)含量的测定。结果:Iso组的上述指标与空白组相比显示心肌肥厚模型制备成功(P<0.01);Pue组数据显示Pue能改善Iso所引起的NO含量降低和其它指标的升高,与Cap组之间指标无明显差异。结论:葛根素对异丙上腺素所致大鼠心肌肥厚的相关细胞因子具有一定的调节作用。
AIM： To study the effect of puerarin （Pue） on related cytokines in myocardial hypertrophy induced by isoproterenol （Iso） in rats. METHODS： 40 SD rats were randomly divided into 4 treatments groups： control group, Iso group, Iso ＋Pue group （Pue group） and Iso ＋ Captoril （Cap） group （Cap group）, with 10 rats each group. Ratio of ventricle weight to heart weight, cardiomyocyte diameter, plasma and myocardial tissue NO, ET and Ang Ⅱ levels were measured. RESULTS： Compared with the control group, Iso did induce significant changes in cardiac hypertrophy （ P 〈 0.01 ）. Pue significantly suppressed decrease of NO levels and increase of ET and Ang Ⅱ levels in Iso-induced hypertrophy. The effect of Pue was similar to that of Cap. CONCLUSION ： These resuits indicate that Pue can adjust the related cytokines in myocardial hypertrophy induced by Iso.
出处
《中成药》
CAS
CSCD
北大核心
2007年第7期960-963,共4页
Chinese Traditional Patent Medicine
