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Rac亚家族主要生物功能及其与肿瘤的关系 被引量:2

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出处 《临床误诊误治》 2007年第1期82-83,共2页 Clinical Misdiagnosis & Mistherapy
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参考文献18

  • 1WETTSCHURECK N,OFFERMANNS S.Rho/Rho-kinase mediated signaling in physiology and pathophysiology[J].J Mol Med,2002,80 (10):629-638.
  • 2ISHIZAKI T,NAITO M,FUJISAWA K,et al.pI60ROCK,a Rho-associated coiled-coil forming protein kinase,works downstream of Rho and induces focal adhesions[J].FEBSLett,1997,404 (223):118-124.
  • 3NARUMIYA S.The small GTPase Rho:cellular functions and signal transduction[J].J.Biochem,1996,120 (2):215 -228.
  • 4JAFFE A B,HALL A.Rho GTPases in transformation and metastasis[J].Adv Cancer Res,2002,84 (1):57-80.
  • 5SUETSUGU S,TAKENAWA T.Regulation of cortical actin networks in cell migration[J].Int Rev Cytol,2003,229:245-286.
  • 6SANDER E E,TEN KLOOSTER J P,VAN DELFT S,et al.Rac downregulates Rho activity:reciprocal balance between both GTPases determines cellular morphology and migratory behavior[J].J Cell Biol,1999,147 (5):1009-1022.
  • 7CASCONE I,GIRAUDO E,CACCAVARI F,et al.Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network.Adherens junctions and myosin light chain as targets of Racl and RhoA[J].J Biol Chem,2003,278 (50):50702 -50713.
  • 8SOGA N,NAMBA N,MCALLISTER S,et al.Rho family GTPases regulate VEGF-stimulated endothelial cell motility[J].Exp Cell Res,2001,269(1):73-87.
  • 9薛妍,毕锋,刘娜,潘阳林,时永全,张学庸.Rho GTPases对肿瘤血管生成相关分子的作用[J].中国生物化学与分子生物学报,2004,20(5):664-669. 被引量:18
  • 10PERVIAZ S,CAO J,CHAO O S,et al.Activation of the racGTPase inhibits apoptos in human tumor cells[J].Oncogene,2001,20 (43):6263-6268.

二级参考文献22

  • 1[1]Qiu R G, Chen J, McCormick F, Symons M. A role for Rho in Ras transformation. Proc Natl Acad Sci USA, 1995,92(25): 11781 ~ 11785
  • 2[2]Ridley A J. Rho GTPases and cell migration. J Cell Sci, 2001, 114(15): 2713~ 2722
  • 3[3]Sherr C J, Roberts J M. CDK inhibitors: positive and negative regulators of Gl-phase progression. Genes Dev, 1999, 13(12): 1501 ~1512
  • 4[4]Pervaiz S, Cao J, Chao O S, Chin Y Y, Clement M V. Activation of the Rac GTPase inhibits apoptosis in human tumor cells. Oncogene,2001, 20(43): 6263 ~ 6268
  • 5[5]Cascone I, Giraudo E, Caccavari F, Napione L, Bertotti E, Collard J G, Serini G, Bussolino F. Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network.Adherens junctions and myosin light chain as targets of Racl and RhoA.J Biol Chem, 2003, 278(50): 50702 ~ 50713
  • 6[6]Hirota K, Semenza G L. Racl activity is required for the activation of hypoxia-inducible factor 1. J Biol Chem, 2001, 276(24): 21166 ~21172
  • 7[7]van Nieuw Amerongen G P, Koolwijk P, Versteilen A, van Hinsbergh V W. Involvement of RhoA/Rho kinase signaling in VEGF- induced endothelial cell migration and angiogenesis in vitro. Arterioscler Thromb Vasc Biol, 2003, 23(2) :211 ~ 217
  • 8[8]Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum S L, Dowdy S F, Kawamura J, Hruska K A. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res, 2001, 269(1) :73 ~87
  • 9[9]Narayan V I, Lori E K, Faton A, Sandra W L, Erik L, Roland H W,Max G, JohnD G, Ann M L, Aimee Y Y, Gregg L S. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor la.Genes Dev, 1998, 12(1) :149 ~ 162
  • 10[10]Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu M M, Simons J W, Semenza G L. Modulation of hypoxia-inducible factor la eexpression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res, 2000, 60(6): 1541 ~ 1545

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