摘要
目的:观察盐酸氯丙嗪在大鼠急性脑损伤中对脑的保护作用。方法:采用Feeney自由落体脑损伤法制备大鼠急性颅脑损伤模型50只,将改良神经功能损害评分(MNSS)为13～18分的30只重型颅脑损伤大鼠列为实验对象,随机分为盐酸氯丙嗪组、胞磷胆碱组和生理盐水组,观察神经功能并进行评分,测定并记录脑含水量,进行统计学分析。结果:盐酸氯丙嗪组的神经功能评分明显高于生理盐水组,两组比较有显著差异(P<0.05);盐酸氯丙嗪组的脑含水量明显少于生理盐水组,两组比较有显著差异(P<0.05)。结论:盐酸氯丙嗪可以明显改善急性脑损伤大鼠的神经功能,减轻脑水肿,有明确的脑保护作用。
To study the protective roles of Chlorpromazine on nerve functions of SD rats with brain injury. Methods： Neurological function of 50 rats with brain injury was evaluated with modified neurological severity scores（MNSS） ,30 ones with 13 ～ 18 M NSS score points were assigned to one of three groups： Chlorpromazine group, Citicoline group, and Normal saline group. MNSS score were recorded every day ,Brain water content was determined by wet/dry weight method. Results：The nerve functions of SD rats in Chlorpromazine group were better than that in Normal saline group（P 〈0.05） ,the brain edem in Chlorpromazine group was less than that in Normal saline group （ P 〈 0.05 ） too. Conclusion ： Chlorpromazine can decrease brain edema of rats with brain injury and improve neurological function.
出处
《临床误诊误治》
2007年第3期81-82,共2页
Clinical Misdiagnosis & Mistherapy
关键词
盐酸氯丙嗪
脑损伤
细胞保护
Chlorpromazine
Brain injury
Cell protection
