摘要
目的观察同步辐射衍射增强成像(diffraction enhanced imaging,DEI)对大鼠骨关节病髁突软骨早期病变的成像效果。方法采用关节盘部分切除法建立大鼠颞下颌关节骨关节病动物模型,以 DEI 观察不同病变时期骨关节病髁突软骨的变化,并与相应标本的组织切片结果对比分析。结果关节盘部分切除后45～60d,髁突 DEI 影像可见软骨内部出现线纹和环状线纹,经组织病理证实为髁突软骨内部的胶原松解和裂隙形成。结论 DEI 可观察到骨关节病早期髁突软骨的胶原松解及微小裂隙等特征性变化,具有潜在的临床应用价值。
Objective To observe the images of early lesions of condylar cartilage of osteoarthritic rats in synchrotron radiation diffraction enhanced imaging （DEI）. Methods The animal model of temporomandibular joint osteoarthrosis was established in rat following the method of partial resection of the joint disc. The changes of osteoarthritic condylar cartilage in different pathological stages were observed by DEI and compared with those in situ histopathological sections. Results With DEI, straight and orbicular lines were detected in condylar cartilage 45 to 60 days after discs resection. The lines were confirmed by histopathology to be collagen degradation and tiny fissure formation inside the cartilage. Conclusions DEI is capable of imaging the early stages of pathological changes of excised condylar cartilage such as collagen degradation and tiny fissure formation, and this technique is of potential value to clinical application.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2007年第7期421-422,共2页
Chinese Journal of Stomatology
基金
国家自然科学基金(10490195
10475090
60172042)
关键词
下颌骨髁状突
诊断显像
骨关节病
Mandibular condyle
Diagnostic imaging
Osteoarthritis
