摘要
目的:评价肝豆状核变性(HLD)患者肾脏近端小管损害的检测方法,为避免HLD误诊及其早期干预治疗提供帮助。方法:对确诊为HLD并除外其他肾小管疾病诱因的38例患者以及31例健康对照者行尿常规检查及24 h尿量、尿糖、尿蛋白、尿钾、钠、氯、钙、磷和尿酸化功能;并对其中37例HLD患者行尿氨基酸定量分析。结果:(1)HLD组的血碱性磷酸酶、24 h尿蛋白、尿钾、尿pH值、尿比重、最初pH值、尿常规中尿蛋白、尿糖、尿潜血、尿红细胞、尿白细胞阳性率较对照组升高,差异有统计学意义(P<0.05)。(2)HLD组的血钾、钙、磷、尿磷、尿可滴定酸较对照组低,差异有统计学意义(P<0.05)。(3)HLD患者24 h尿氨基酸高于正常值。结论:HLD患者存在不同程度的肾脏近曲小管功能受损。
Objective： To observe the disorders of the renal proximal tubule by routine and special laboratory examinations to avoid misdiagnosis and early intervene of hepatolenticular degeneration （HLD, Wilson＇s disease）. Methods： Urine routine test, 24 hour urine volume, glucose, protein, potassium, sodium, chloride, calcium, phosphate and urine acidization function were examined in 38 Wilson＇ s disease patients and 31 normal controls. Urine aminoacid quantity analysis was tested in 37 out of the 38 Wilson＇ s disease cases and the data was analysed. Results： （ 1 ） Plasma ALP, 24 hour urine protein, 24 hour urine potassium, urine pH value, urine density, primary pH value and protein, glucose, OB, REC and WBC of the urine routine test in HLD group were siginificantly higher than those in the control group （P 〈 0.05）. （2） The plasma potassium, calcium, phosphate, urine phosphate and urine titered acid of HLD group were siginificantly lower than those in the control group （P 〈 0.05）. （3） Twenty-four hour AA was higher than normal in HLD. Conclusion： The functional disorders of the renal proximal tubule are present in HLD to some degree.
出处
《天津医药》
CAS
北大核心
2007年第7期503-505,共3页
Tianjin Medical Journal
关键词
肝豆状核变性
肾小管
氨基酸尿
肾性
骨和骨组织
范科尼综合征
hepatolenticular degeneration kidney tubules aminoaciduriarenal bone andbones Fanconi syndrome
