摘要
目的评价LFTP方案治疗中晚期大肠癌的疗效和毒副作用。方法吡喃阿霉素(THP)35 mg/m2,静滴,第1天;顺铂(DDP)20 mg/m2,静滴,第1~5天;亚叶酸钙(LV)200 mg,静滴,第1~5天;氟尿嘧啶(5-Fu)500 mg/m2,静滴6 h,第1~5天;21 d为一个周期。结果96例中CR 7例(7.6%),PR 36例(39.1%),PD 20例(21.8%),总有效率46.7%。本组主要毒副作用为骨髓抑制和口腔黏膜炎,无化疗相关性死亡。结论LFTP方案治疗中晚期大肠癌疗效较好,毒副反应可以耐受,有临床应用价值。
Objective To evaluate the clinical efficacy and the toxicity of the combination chemotherapy（LFTP regimen） with pirarubicin （THP）, fluorouracil （5-Fu）, leucovorin （LV） and cisplatin （DDP） in the treatment of advanced colorectal cancer. Methods Ninety-six patients with advanced colorectal cancer were treated with LTFP regimen. THP was given iv gtt on the first day at a dose of 35 mg/m^2 , DDP was given iv gtt on the days 1-5 at a dose of 20 mg/m^2, LV was given iv gtt on days 1-5 at a dose of 200 mg/ mE and 5-Fu was given at a dose of 500 mg/m^2 on the days 1-5 by intravenous drip for 6 hours each day. The chemotherapy was repeated every 21 days and a course of treatment included three cycles. Results Seven patients showed complete response （7.6%）,36 partial response （39.1%） and 20 had progression of disease （21.8%）. The total effective rate was 46.7%. The main toxic effects were myelosuppression and sto- matitis. There was no chemotherapy-related death. Conclusion L^FP regimen is effective and well tolerated in the treatment of advanced colorectal cancer. Therefore, it has significance for clinical therapy.
出处
《中国肿瘤临床与康复》
2007年第3期235-237,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
