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新疆汉族男性高尿酸血症与代谢综合征相关性研究 被引量:19

The correlated study of hyperuricemia and metabolic syndromes among males of Han ethnicity in Xinjiang
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摘要 目的:了解新疆汉族男性高尿酸血症与代谢综合征的相关性。方法:对1469例汉族男性体检者的身高、体重、腰围、臀围、收缩压(SBP)、舒张压(DBP)进行测量,并检测其血液生化指标,包括血尿酸(SUA)、空腹血糖(FBG)、尿素氮(BUN)、肌酐(SCR)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)。结果:本研究人群中高尿酸血症检出率为39.1%,代谢综合征的检出率为18%。高尿酸组体质指数(BMI)、腰臀比(WHR)、SBP、DBP、FBS、TG、TC、LDL-C与代谢综合征的相关指标均高于正常组,且均与血尿酸密切相关;正常组和高尿酸组相比,肥胖、腹部脂肪堆积、高血糖、高血压、高甘油三酯血症检出率差异均有统计学意义(P<0.05),高尿酸血症组发生肥胖、腹部脂肪堆积、高血糖、高血压、高甘油三酯血症的危险分别是尿酸正常者的3.097、2.633、2.226、2.094、3.058倍(P<0.05)。结论:代谢综合征相关危险因子如肥胖、腹部脂肪堆积、高血糖、高血压、高甘油三酯血症等是新疆汉族男性发生高尿酸血症的危险因素,应加强对高尿酸血症和代谢综合征的健康教育。 Objectives: To investigate the relationship between serum uric acid (UA) and metabolic syndrome (MS) among males of Han ethnicity in Xinjiang. Methods: The blood samples were collected from January to May 2006 in Urumqi, It included 1 496 subjects. These subjects people were analyzed for Serum uric acid(SUA), the fasting blood sugar (FBS), serum triglyceride( TG), serum total cholesterol( TC), serum high density lipoprotein (HDL-C), and serum low density lipoprotein (LDL-C) as well as biochemistry targets. Data were analyzed using the Pearson chi-square test and Mann-Whitney Test and the Mantel-Haenszel test for linear trend respectively. Results: The prevalence of complete MS and hyperuricemia in the present study were 18% and 39. 1%. Blood ressure, FBS ,bodymass index (BMI),waist/hip ratio, TG,TC,LDL-C were significantly higher in peoples with hyperuricemia than in normal persons and these factors were strongly related to serum uric acid too, The components of metabolic syndrome such as fat, hyperglycemia, hypertension, dyslipidemia were showed closely correlated with SUA. The Odds ratios of these metabolic diseases in hyperuricemia group were 3. 097-times, 2. 633-times, 2. 226-times, 3. 058-times to SUA normal group respectively. They all had positive correlations. Conclusions: Hyperuricemia is closely linked to the various components of the metabolic syndrome, more emphasis should be put on the evolving control and prevalence of hyperuricemia and metabolic syndrome among males of Han ethnicity in Xinjiang.
出处 《新疆医科大学学报》 CAS 2007年第6期535-538,共4页 Journal of Xinjiang Medical University
基金 教育部高等学校博士点科研基金项目(20060760002) 新疆高校创新群体科研基金(XJEDV200G09) 新疆维吾尔自治区劳动卫生与环境卫生学重点学科建设基金
关键词 高尿酸血症 代谢综合征 相关性 hyperuricemia metabolic syndrome correlation
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参考文献17

  • 1Conen D,Wietilisbach V,Bovet P,et al.Prevence of hyperuricmia and relation of serum uric acid with cardiovascular risk factors in developing country[J].BMC Public Health,2004,4:9.
  • 2Krishnan E,Kwoh CK.Hyperuricemia and incidence of hypertension among men without metabolic syndrome hypertension[J].Hypertension,2007,49(2):298-303.
  • 3Onat A,Uyarel H,Hergenc G,et al.Serum uric acid is a determinant of metabolic syndrome in a population-based study[J].Am J Hypertens,2006,19 (10):1055-1062.
  • 4中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中国糖尿病杂志,2004,12(3):156-161. 被引量:3059
  • 5Wi-Shankar A,Klein R,Klein BE,et al.The association between serum uric acid level and long-term incidence of hypertension:Population-based cohort study[J].J Hum Hypertens,2006,20(12):937-945.
  • 6Niskanen LK,Laaksaoen DE,Nyyssonen K,et al.Uric acid level as a risk factor for cardiovascular and all cause mortality in middle aged men:a prospective cohort study[J].Arch Intern Med,2004,164(14):154-155.
  • 7Heinig M,Johnson RJ.Role of uric acid in hypertension,renal disease,and metabolic syndrome[J].Cleve Clin J Med,2006,73(12):1059-1064.
  • 8Quinones-Galvan A,Natali A.Effect of insulin on uric acid excretion in humans[J].Am J Physiol,1995,268:1-5.
  • 9Markkola CU,Jarvinen HY.Hyperuricemia and insulin resistance[J].J Clin Endo Metab,1994,78:25-29.
  • 10Lohsoonthorn V,Dhanamun B,Williams MA.Prevalence of hyperuricemia and its relationship with metabolic syndrome in thai adults receiving annual health exams[J].Arch Med Res,2006,37(7):883-889.

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