摘要
本文报道了在海拔3700m高原缺氧地区,家兔肢体缺血再灌注后引起急性肺损伤肺组织病理形态学及超微结构的变化。40只动物随机分为正常对照组、单纯缺血组、再灌注30min组、再灌注60min组、再灌注120min组。结果表明:再灌注后各组肺组织均有不同程度的病理改变,主要表现为毛细血管扩张、充血。大量的多核白细胞聚集、贴壁。红细胞淤集,并呈扭曲、变形状。基底膜增宽、增厚,甚至出现结构模糊的溶断现象。I型上皮细胞肿胀,Ⅱ型上皮细胞表面微绒毛减少,板层体排空。这些病理变化与ARDS时病变相似,但区别在于未见血小板微血栓及透明膜形成。实验结果提示;肢体缺血再灌注后可以导致急性肺损伤,这种急性肺损伤的发生与多核白细胞有十分密切的关系,本文对此进行了讨论。
The histopathological and ultrastructural changes of the acute lung injury following reperfusion after ischemia in the hind limbs at high-altitude were studied. Forty rabbits were separated into five groups, (normal control, ischemia control, reperfusion 30 minutes, reperfusion 60 minutes and reperfusion 120 minutes). The experimental animals were subjected to four hours of hind limbs ischemia, then reperfused. It was found that microvascu-lar congestion, aggregation of large amount of polymorphonuclear leukocytes (PM) and degranulation of PMN were found at 30, 60, 120 minutes after reperfusion. Type I pneumocytes became swollen and deteriorated. The lamellar bodies of Type Ⅱ pneumocytes were evacuated rapidly. The results suggest that polymorphonuclear leukocyte plays an important role in the acute lung injury following reperfusion after ischemia in the hind limbs at high-altitude.
出处
《骨与关节损伤杂志》
1997年第1期30-32,共3页
The Journal of Bone and Joint Injury
