摘要
核因子-κΒ(NF-κΒ)是一种重要的核转录因子,它参予细胞氧化应激的信号传递,调控多种基因的表达。它的异常激活或完全抑制与多种疾病的发生有关。糖尿病及其并发症是炎症性疾病,伴有NF-κΒ转录活性的异常。近来的研究更显示无论糖尿病病程长短,糖尿病患者体内的许多组织均有NF-κΒ的异常表达,而某些针对NF-κΒ的抗炎治疗对于糖尿病患者是有益的。因此,深入研究NF-κΒ和糖尿病的关系,对于人类最终战胜糖尿病有重要意义。
The transcription factor nuclear factor- kappa B （NF-κB） has been proposed as a critical bridge between oxidant stress and gene expression. Exposure of cells to inflammatory, infectious, or other stressful stimuli results in release and translocation of NF-κB into the nucleus. And activation of the transcription factor NF-κB has been suggested to participate in inflammatory disorders, such as diabetes and its complications. Recent studies showed that activated NF-κB presented in different tissues of patients with a new onset or a long history of diabetes, and an anti-inflammatory action through a reduction of NF-κB activation might be beneficial to diabetic patients.
出处
《医学研究生学报》
CAS
2007年第3期310-314,共5页
Journal of Medical Postgraduates
基金
江苏省六大人才高峰重点课题基金资助项目(批准号:2005A2)
南京军区南京总医院科研基金资助项目(批准号:2005036)
关键词
核因子-κΒ
糖尿病
炎症
氧化应激
Nuclear factor kappa B
Diabetes
Inflammation
Oxidant stress
