摘要
目的研究KIO3毒性与甲状腺自体免疫疾病的关系。方法以亚慢性毒性(90d喂养)试验。雌性Wis-tar大鼠随机分为8组,每组10只。分别给予含不同剂量的KIO3去离子饮水,各组均饲以正常大鼠粉状饲料喂养3个月后心脏采血处死大鼠,分离血清测定甲状腺激素(TT3、TT4和rT3)水平。结果碘酸钾使脾体比升高,6000μg/L组血白细胞与对照组相比明显升高,最高剂量组rT3水平降低,与对照组相比,差异具有显著性意义(P<0·05)。随着剂量升高,血胆固醇明显升高、总蛋白明显下降(P<0·05)。最高剂量组视网膜电图(ERG)a、b波振幅均明显下降。结论碘酸钾可能使机体甲状腺相关自身免疫性眼病性眼病发生。
Objective To explore the relatioship between the toxicity of KIO3 and autoimmune orbitopathy associated with thryroid. Methods Subchronic toxicity of KIO3 was evaluated by 90 day feeding test. Eighty weanling female Wistar rats with the weight of from 50g to 60g were divided into 8 groups randomly each consisted of 7. The rats in one group were given deionized water as a control group. The rats in other 7 groups were given deionized water containing various doses of KIO3. Food intakes, water intakes and body- weight were determined every week. 13 weeks after rats were selected randomly in control and high dose KIO3 groups for electrorefinogram （ERG） examination. Haematological values, thyroid hormone values and clinical chemistry parametem were measured. Organs were separated carefully for weighing and pathology analysis. Results The level of rT3 of the highest KIO3 group was significantly lower than that of the control group （ P 〈 0.05）. Serums TC raised sensitively in the highest KIO3 groups. Serums TP decreased sensitively in the highest KIO3 groups In addition, the amphtude of a and b waves of ERG were significantly lower in the highest KIO3 group rats compared to the control rats （ P 〈 0.05）. Conclusion The overtake of potassium iodate may lead to the occurrence of Graves disease, especially thyroid associated autoimune ophthalmapathy.
出处
《中国热带医学》
CAS
2007年第8期1293-1295,共3页
China Tropical Medicine
基金
国家自然科学基金重点项目(30230330)
