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铜绿假单胞菌耐药性变迁及其防治 被引量:4

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摘要 目的探讨临床分离铜绿假单胞菌(PAE)耐药性变迁及其防治。方法对河南大学准河医院1999~2006年临床分离菌株K-B法药敏试验结果进行分析。结果629株PAE占总菌株数的13.8%,居首位。PAE对环丙沙星等13种临床常用抗菌药物耐药率均呈增高趋势;对哌拉西林等5种药耐药率变化类型相似,近三年看属上升趋势;对头孢曲松73.0%的耐药率保持相对稳定;对多黏菌素等4种药耐药率均有下降。PAE对头孢噻肟等8种药耐药率高达75.0%~100%,对9种药物较敏感依次为:多黏菌素、亚胺培南、环丙沙星、头孢吡肟、头孢他啶、哌拉西林/他唑巴坦、阿米卡星、左氧氟沙星、头孢哌酮,总耐药率均<30%。结论PAE是医院感染最常见致病菌,耐药性很强。PAE感染可依据药敏结合临床选用头孢他啶、环丙沙星等抗菌活性强的药物,对PAE严重感染可选亚胺培南或采取β-内酰胺类与阿米卡星或左氧氟沙星联合用药方案。
出处 《医药论坛杂志》 2007年第12期75-76,共2页 Journal of Medical Forum
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