摘要
目的:探讨细胞黏附分子E-钙粘素和β-连接素在40岁以下宫颈病变及宫颈癌组织中的表达。方法:应用免疫组化SP法检测E-钙黏素和β-连接素在30例40岁以下子宫颈癌、26例宫颈上皮内瘤变(CIN)及10例正常子宫颈组织中的表达。结果:E-钙黏素和β-连接素在CIN异常表达率为42%、39%,与正常宫颈比较差异有显著性(P<0.05);E-钙黏素和β-连接素在宫颈癌异常表达率为73%、70%,E-钙黏素在宫颈癌的异常表达与CIN及正常宫颈比较差异有显著性(P<0.05,P<0.01)。β-连接素在宫颈癌的异常表达显著高于正常宫颈(P<0.01)。结论:E-钙粘素和β-连接素蛋白表达的下调可能是年轻妇女CIN进展为宫颈癌的因素。
Objective：To investigate the expression of E-cadherin and β-catenin in cervical intraepithelial neoplasia（CIN） and cervical cancer. Methods：Immunohistochemical S-P method was used in 30 cervical cancer,26 CIN and 10 normal cervical tissue specimens aged〈40 years for the expression of E-cadherin and β-catenin. Results：Abnormal immunoreactivity for E-cadherin （42%） and β- catenin （39%） in CIN were observed respectively, which were significant differences from normal group（P〈0.05）. Abnormal immunoreactivity for E-cadherin and β-catenin were 73% and 70% respectively. Abnormal immunoreactivity for E-cadherin in cervical cancer was significant difference compared with CIN and normal group （P〈0.05,P〈0.01）. Abnormal expression of β-catenin in cervical cancers was higher than that in normal group（P〈0.01）. Concluslon：Decreased expression of E-cadherin and β-catenin in cervical may influence CIN persistent to cervical tissue cancer.
出处
《现代医药卫生》
2007年第15期2222-2223,共2页
Journal of Modern Medicine & Health
基金
肇庆市科学技术基金资助项目(2005E332)
