摘要
目的:研究复方创伤药对创伤伤口的治疗作用,比较中药和西药对皮肤创伤的疗效作用,寻求经济便捷而又有效的创伤愈合药,探讨其初步机制。方法:通过查找比较各种中药的药理及应用,以野菊花20g,蒲公英30g,黄柏30g,三七30g,地榆30g,配成一副中药(实验组),建立家兔创伤模型,以伤口愈合面积、愈合率、结痂和病理切片作为指标,与目前常用药磺胺嘧啶银霜(对照组)对照,观察该药促进伤口愈合的作用。结果:实验组与空白组(涂以碘酒)比较,实验组能明显提高家兔的伤口愈合率(P<0.05);实验组与对照组比较,伤口愈合率无明显差异(P>0.05);与空白组比较,实验组和对照组均能促进表皮形成,减少炎症细胞浸润,加速胶原纤维增生形成瘢痕。结论:该复方中药在创伤愈合中有显著的作用,能促进伤口血管重建,减少炎症细胞的浸润,加速胶原纤维的增生形成瘢痕,防止伤口感染。
Objective To study the therapeutic effect of a Chinese vulneraria in compound prescription on the wound of skin injury, compare the efficacy of the Chinese and Western medicine in the management of skin injury, and develop a cheap, convenient and effective vulneraria. Methods A new Chinese vulneraria was confected with Flos Chrysanthemi Indici 20 g,Herba Taraxaci 30 g,Cortex Phellodendri 30 g,Radix Notoginseng 30 g,and Radix Sanguisorbae 30 g by analyzing the pharmacology and roles of various Chinese herbal medicines. A rabbit model of skin injury was established and the area of wound healing, curative rate, scar formation, and pathological sections were used as an indicator. The therapeutic effect of this vulneraria was observed and compare with that of the routine sulfadiazine silver ointment for skin wound. Results The wound healing rate of the rabbits was markedly higher in the vulneraria group than in the vacant group （P 〈 0.05）. There was no significant difference in the wound healing rate between the vulneraria group and the sulfadiazine silver group （P 〉 0.05）. Both of this vulneraria and the sulfadiazine silver ointment could promote the formation of epidermis, decrease the inflammatory cell infiltration, and accelerate the proliferation of fibroblasts, resulting in scar formation. Conclusions This Chinese vulneraria in compound prescription plays a significant role in skin wound healing. It can enhance the vessel reconstruction in skin wound, decrease the inflammatory cell infiltration, accelerate the proliferation of fibroblasts to form scar, and protect the wound against infection.
出处
《实用医学杂志》
CAS
2007年第14期2129-2131,共3页
The Journal of Practical Medicine
基金
中山大学2005年实验室开放基金资助项目(编号:KF2005017)
关键词
创伤和损伤
皮肤
中草药
伤口愈合
兔
Wounds and injuries Skin Drugs, Chinese herbal Wound healing Rabbits
