摘要
采用毛细管气相色谱法测定α-硫辛酸中环已烷、乙酸乙酯、苯和丙酮的含量。选用HP-FFAP色谱柱、程序升温、FID检测器,载气为氮气,以二氯甲烷为内标法进行定量。在选定的色谱条件下,4种有机溶剂残留物浓度与相应色谱峰呈良好的线性关系,平均回收率为99.8%～100.6%,RSD为0.82%～1.33%(n=3),检出限为7.28～13.46μg/mL。该方法适用于α-硫辛酸样品有机溶剂残留量的测定。
A capillary gas chromatography method for the determination of residual organic solvent cyclohexane, ethyl acetate, benzene and acetone in alpha lipoic acid was established. HP - FFAP capillary column was used with nitrogen gas as carrier and FID as detector using dichloromethane as the internal standard. The linearity of the four residual solvents was satisfactory （r 〉 0. 999）. The average recoveries were 99.8% - 100.6% with RSD of 0.82% - 1.33%. The limit of detection was 7.28 - 13.46 μg/mL. The contents of the four residual organic solvents in three hatches of samples all reached the standard requirements. The method is simple, rapid and accurate for the determination of residual organic solvents in alpha lipoic acid.
出处
《化学分析计量》
CAS
2007年第4期39-41,共3页
Chemical Analysis And Meterage
关键词
硫辛酸
有机溶剂残留量
毛细管气相色谱
alpha lipoic acid, residual organic solvents, capillary gas chromatography
