期刊文献+

胰岛素增敏剂的临床应用进展 被引量:6

下载PDF
导出
摘要 胰岛素抵抗是指胰岛素的外周靶组织(主要为骨骼肌、肝脏和脂肪组织)对内源性或外源性胰岛素的敏感性和反应性降低.导致生理剂量的胰岛素产生低于正常的生理效应。研究认为胰岛素抵抗和胰岛13细胞功能(简称13细胞功能)受损构成了大多数2型糖尿病患者发病的两个主要病理生理环节。在环境和遗传因素的背景下胰岛素抵抗的发生可能更早.甚至追溯到糖耐量正常阶段.
作者 邢小燕
出处 《临床药物治疗杂志》 2007年第4期24-28,共5页 Clinical Medication Journal
  • 相关文献

参考文献27

  • 1[1]Ferrannini E.Insulin resistance versus insulin deficiency in noninsulin-dependent diabetes mellitus:problems and prospects.Endocrine Reviews,1998,19:477-490
  • 2[2]Meigs JB,Wilson P.WF,Nathan DM,et al.Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham offspring Studies.Diabetes,2003,8:2160-2167
  • 3[3]Yonemitsu S,Nishimura H,Shintani M,et al.Troglitazone induces GLUT4 translocation in L6 myotubes.Diabetes,2001,50:1093-1101
  • 4[4]Arner P.Free fatty acids-do they play a central role in type 2diabetes.Diabetes,Obesity & Metabolism,2001,3 (Suppl.1):S11-S19
  • 5[5]Banerji M,Lebovitz HE & Dugbartey M.Rosiglitazone selectively increases subcutaneous but not visceral adipose tissue mass in type 2 diabetes mellitus.Diabetes,2001,50 (Suppl 2):A90
  • 6[6]Smith S,Boam DS,Bretherton-Watt D,et al.Rosiglitazone increases pancreatic islet area,density and insulin content,but not insulin gene expression.Diabetes,1998,47 (Suppl.1):A18
  • 7[7]Patel J,Weston WM & Hemyari P.Rosiglitazone (RSG) decreases insulin resistance (IR) and improves beta-cell function (BCF) in patients with type 2 diabetes mellitus.Endocrine Society 81st Annual Meeting:Program and Abstracts,1999,470:Abstract P3-P153
  • 8[8]Aronoff S,Rosenblantt S,Braithwaite S,et al.Pioglitazone hydrochloride monotherapy improves glycemie control in the treatment of patients with type 2 diabetes:a 6-month randomized placebo-controlled dose -response study.The Pioglitazone 001Study Grope.Diabetes Care,2000,23:1605-1611
  • 9杨兆军,颜树峰,邢小燕,王宣,李光伟.盐酸吡格列酮对磺脲类和双胍类药物联合治疗失效的2型糖尿病患者的疗效观察[J].中国综合临床,2005,21(12):1099-1101. 被引量:9
  • 10[10]Raskin P,Dole JF & Rappaport EB.Rosiglitazone improves glycemic control in poorly controlled,insulin-treatd type 2 diabetes (T2D).Diabetes,1999,48 (Suppl.1):A94

二级参考文献7

  • 1Matthaei S,Stumvoll M,Kellerer M,et al.Pathophysiology and pharmacological treatment of insulin resistance[J].Endocrine Reviews,2000,21(6):585-618.
  • 2Schernthaner G,Matthews DR,Charbonnel B,et al.Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus:a double-blind,randomized trial[J].J Clin Endocrinol Metab,2004,89(12):6 068-6 076.
  • 3Pavo I,Jermendy G,Varkonyi TT,et al.Effect of pioglitazone compared with metformin on glycemic control and indicators of insulin sensitivity in recently diagnosed patients with type 2 diabetes[J].J Clin Endocrinol Metab,2003,88(4):1 637-1 645.
  • 4Mimura K,Umeda F,Hiramatsu S,et al.Effects of a new oral hypoglycaemic agent (CS-045) on metabolic abnormalities and insulin resistance in type 2 diabetes[J].Diabet Med,1994,11(7):685-691.
  • 5Fullert S,Schneider F,Haak E,et al.Effects of pioglitazone in nondiabetic patients with arterial hypertension:a double-blind, placebo-controlled study[J].J Clin Endocrinol Metab,2002,87(12):5 503-5 506.
  • 6Aronoff S,Rosenblatt S,Braithwaite S,et al.Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes:a 62-month randomized placebo-controlled dose-response study.The Pioglitazone 001 Study Group[J].Diabetes Care,2000,23(11):1 605-1 611.
  • 7Kelly IE,Han TS,Walsh K,et al.Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes[J].Diabetes Care,1999,22(2):288-293.

共引文献8

同被引文献53

引证文献6

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部