腹腔热灌注化疗联合全身化疗治疗老年癌性腹水的临床研究被引量：8

Clinical study on hyperthermic peritoneal perfusion with oxaliplatin plus systemic chemotherapy for senile patients with malignant ascites

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摘要目的研究草酸铂腹腔热灌注联合5-氟脲嘧啶／亚叶酸钙（5-FU／LV）方案治疗老年癌性腹水的疗效及不良反应。方法40例癌性腹水病人，随机分为2组，治疗组21例采用草酸铂腹腔热灌注。灌注后行腹腔深部热疗，使其温度控制于41℃～43℃，持续90min。腹腔化疗后第2天起予以5-FU／LV方案行全身化疗。对照组19例单用顺铂腹腔灌注化疗，并行5-FU／LV方案行全身化疗。2周期后评价疗效。结果治疗组和对照组有效率分别为71．4％和36．8％（P〈0．05）。主要不良反应为急性腹痛、恶心、呕吐以及骨髓抑制，2组间无显著性差异。结论草酸铂腹腔热灌注化疗联合5-FU／LV方案治疗老年性癌性腹水效果较好，且不良反应可耐受。 Objective To evaluate the effects and toxicities of hyperthermic peritoneal perfusion （HPP） with oxaliplatin plus 5-FU/LV for senile patients with malignant ascites. Methods Forty patients with malignant ascites were randomly divided into two groups. In the treatment group, 21 patients underwent intraperitoneal perfusion with L-OHP, followed by hyperthermia which maintained the cavity＇ s temperature at 41 ℃ -45 ℃ for 90 minutes. Each was treated with 5- FU/LV from the next day. The control group received intraperitoneal cisplatin perfusion and chemotherapy with 5-FU/LV. The efficacy and toxicities were evaluated after two periods. Results The overall response rates in two groups were 71.4% and 36. 8% respectively（ P 〈 0. 05 ）. The main complication was acute abdomenpain, nausea, vomiting and marrow suppression. However, there was no significant difference between two groups. Conclusions The HPP with oxaliplatin plus 5-FU/LV is feasible in the treatment of senile malignant ascites. It is safe and could be tolerated.

作者王峻杨民刘福银樊卫飞孟丽娟蒲骁麟

机构地区江苏省省级机关医院肿瘤科

出处《实用老年医学》 CAS 2007年第4期252-254,共3页 Practical Geriatrics

关键词腹腔热灌注化疗草酸铂癌性腹水 hyperthermic peritoneal perfusion chemotherapy oxaliplatin malignant ascites

分类号 R730.53 [医药卫生—肿瘤]

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