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中医解毒祛瘀滋阴法对SLE患者生存质量的影响研究 被引量:21

Investigation on the Effect of Traditional Chinese Medical Jieduquyuziyin Methods on the Quality of Life with Systemic Lupus Erythematosus
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摘要 目的:应用SF-36量表评价中医解毒祛瘀滋阴法治疗系统性红斑狼疮(SLE)对其生存质量的影响。方法:147例女性SLE患者被随机分为中西结合组(79例)和西药组(68例),西药组口服强的松为主治疗,中西结合组在强的松基础上结合解毒祛瘀滋阴药治疗。两组均以3个月为1个疗程,连续治疗观察2个疗程。先对SF-36量表的信度和效度进行评价,然后开展SLE患者治疗前后的生存质量调查评估。结果:SF-36各维度得分及总分两次评估的相关系数均≥0.85以上,Cronbach’α系数均>0.8,生理因子和心理因子的实际结构与量表的理论结构基本一致。治疗前比较,两组SLE患者的各维度得分和综合评分均显著低于中国常模(P<0.05);治疗前后比较,中西结合组各维度得分和综合评分均显著升高(P<0.05),而西药组中总体健康(GH)和社会功能(SF)得分差异无显著性(P>0.05),其它也均显著提高(P<0.05);治疗后比较,两组间躯体疼痛(BP)和心理健康(MH)得分差异无显著性(P>0.05),其它均有显著性差异(P<0.05)。结论:SF-36量表的信度和效度良好,适用于对SLE生存质量的评价。中医解毒祛瘀滋阴法结合激素治疗SLE在改善患者生命质量方面,与单用西药相比存在明显优势,值得临床推广应用。 Objective: To determine the quality of life(QOF) of the patients with systemic lupus erythematousus(SLE) by short form -36 (SF -36), before and after treated by the traditional Chinese Medical(TCM) Jieduquyuziyin methods. Methods :147 cases of SLE were randomly divided into the Integrated traditional Chinese and western medicine group(79 cases) and the western medicine group(68 cases). The western medicine group was treated mainly with prednisone only, while the integrated traditional Chinese and western medicine group with Jieduquyuziyin methods on the basis of normal western medicine. Both groups were treated for 2 therapy course, 3 months as a course. The reliability and availability of SF- 36 was investigated and determined first. Then the QOF of patients with SLE were researched and determined. Results: The coefficients of both each sub - scale and total score of SF - 36 were more than 0.85, the coefficinet of Cronbach's a more than 0.8. The actual makeup and theoretic makeup of physical factor and mental factor was consistent basically. To be compared before therapy,the scores of each sub -scale and total form in two groups of SLE were lower than those in the Chinses normal model( P 〈0.05) ;To be compared with before and after therapy,the sub -scale and total scores in the integrated traditional Chinese and western medicine group increased significantly( P 〈0.05) ,the other sub - scale in the western group also increased significantly ( P 〈 0.05 ) but the score of GH and SF ( P 〉 0.05 ). To be compared after therapy,the were no marked difference in the score of BP and MH( P 〉 0.05) between the integrated traditional Chinese and western medicine group and western group, while being obvious difference in other sub - scale and total scores( P 〈 0. 05). Conclusions: The form of SF- 36 is well fitted for determining the QOF of SLE patients,which has a better reliability and availability. Treating SLE with TCM Jieduquyuziyin methods integrated prednisone has better effect on the QOF than therapy by the western medicine only,which is worth generalizing and applying.
出处 《中华中医药学刊》 CAS 2007年第8期1599-1602,共4页 Chinese Archives of Traditional Chinese Medicine
基金 国家中医药管理局资助项目(02-03LP29)
关键词 系统性红斑狼疮 生命质量 SF-36量表 强的松 解毒祛瘀滋阴法 systemic lupus erythematosus quality of life the MOS 36 item short form health survey ( SF - 36) prednisone Jieduquyziyin methods
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