摘要
乌苏里黎芦碱（Ｖｅｒａ－Ｕ）２０ｕｇ／ｋｇ腹腔注射（ｉｐ）明显降低小鼠自发活动数，４０μｇ／ｋｇｉｐ可显著对抗苯甲酸钠咖啡咽所致的运动性兴奋。４０μｇ／ｋｇｉｐ可加强戊巴比妥钠的催眠作用，增强氯丙嗪的中枢抑制作用，６０μｇ／ｋｇ可加强哌替啶的镇痛作用。
The results showed that Vera-U 20ug.kg -1 ip decreased obviously spontaneous activity of mice.Vera-U40ug.kg -1 opposed significantly excited conditions induced by CNB.The same dose of Vera-U ip potentiated the bypnotication of subthresbold dose of sodium pentobatbital to produce hypnosis and enhanced obviously sedative action of subthreshouid dose of chlorpromazine.Vera-U 60ug.kg -1 ip augmented remarkably the analgesic action of subthreshould dose of pethidine.These results indicated that Vera-U has a well sedative action and the synergism between Vera-U and drugs inhibiting CNS is well existed.
出处
《大连医科大学学报》
CAS
1997年第1期11-13,共3页
Journal of Dalian Medical University
关键词
乌苏里黎芦碱
中枢抑制作用
药理
veratrum nigrum var
ussuriense
sedative action
synergizm
