摘要
目的探讨总摄氟量与儿童氟斑牙患病率间的剂量-效应关系及总摄氟量的基准剂量。方法选择江苏省某县新淮村(非病区村,饮水氟含量0.36±0.11mg/L)和瓦庙村(地方性氟中毒重病区村,饮水氟含量2.46±0.80mg/L)所有在校的8～13岁儿童为调查对象,并根据儿童总摄氟量的不同将两村儿童分为5个不同的接触组,即:<1.00mg/人·日、1.00～mg/人·日、2.00～mg/人·日、3.00～mg/人·日、≥4.00mg/人·日5组,分别统计各组儿童的氟斑牙和缺损型氟斑牙患病率。结果随着总摄氟量的增加,儿童氟斑牙和缺损型氟斑牙患病率逐渐增加,呈显著的剂量-效应关系。根据总摄氟量与氟斑牙和缺损型氟斑牙患病率间的剂量-效应关系计算的总摄氟量的基准剂量的95%下限分别为1.40mg/人·日和1.78mg/人·日,由此所得的总摄氟量的参考剂量分别为1.40mg/人·日和1.78mg/人·日。结论本次研究所得的总摄氟量的参考剂量低于国家卫生行业标准中规定的饮水型氟中毒病区8～15周岁儿童的总摄氟量的允许限量。因此,该标准在本次调查地区是否适用值得商榷。
Objective To explore the relationship between the daily total fluoride intake and the children＇s dental fluorosis, and to calculate the BMD and BMDL of daily total fluoride intake using the BenckMark Software. Methods Hinhuai village （ non - endemic fluorosis area, drinking water fluoride： 0.36±0.11 mg/L） and Wamiao village （severely endemic fluorosis area, drinking water fluoride： 2.46 ±0.80 mg/L） were selected for this study. The 8 to13 years old students in two villages were recruited in the study. The students were divided into 5 subgroups according their daily total fluoride intake： 〈 1.00mg/（ p ＊ d）,l.00- mg/（p＊d）,2.00 - mg/（p＊ d）,3.00 - mg/（p＊d）,≥4.00 mg/（p＊ d）. The prevalence of dental fluorosis and more severe defect dental fluorosis were investigated in each group. Results Higher daily total fluoride intake were significantly associated with higher prevalence of dental fluorosis and the more severe defect dental fluorosis, which included significant dose - response relationships between daily total fluoride intake and these two degrees of dental fluorosis. The BMDL were 1.40 mg/（ p ＊ d ） and 1.78 mg/（ p ＊ d ） respectively, calculated by these dose - response relationships. So the RfD were 1.40 mg/（ p＊d） and 1.78 mg/（p ＊ d） calculated by the BMDL. Conclusions The RfDs of this study were very lower than that the limit value of the ＂Hygienic standard for daily total fluoride intake＂ （ WS/T 87 - 1996 ） for 8 to15 years in the drinking water type endemic fluorosis area. So that, whether the ＂WS/T 87 - 1996＂ was suitable for this study field or not, was needed to future study.
出处
《中国地方病防治》
北大核心
2007年第4期254-257,共4页
Chinese Journal of Control of Endemic Diseases
基金
江苏省人民政府和中华人民共和国国土资源部地质调查局资助(项目编号:200312300008)
江苏省地方病防治协会(X200327)
关键词
总摄氟量
氟斑牙
剂量-效应关系
Total fluoride intake
Dental fluorsis
Dose - respomse relationships
