期刊文献+

伊马替尼治疗加速期和急变期慢性髓细胞性白血病的临床研究 被引量:2

Imatinib in treatment of patients with chronic myelogenous leukemia at accelerated phase and blast crisis
下载PDF
导出
摘要 慢性髓细胞性白血病(CMI.)具有特殊的细胞遗传学异常。以bcr/abl融合基因的激酶作为靶点的药物伊马替尼(imatinib),其商品名为格列卫(Glivec),对CML显示出了良好的治疗效果,其对慢性期患者的分子生物学缓解率达75%以上,但对进入加速期及急变期CML的治疗效果国内报道不多。本研究总结了本院2002年以来18例加速期及急变期CML应用伊马替尼治疗的效果,供同行参考。
出处 《第二军医大学学报》 CAS CSCD 北大核心 2007年第8期928-928,F0003,共2页 Academic Journal of Second Military Medical University
  • 相关文献

参考文献11

  • 1Kantarjian H M, Shan J, Smith T, et al. Response to therapy is independently associated with survival prolongation in chronic myelogenous leukemia in blastie phase[J]. Cancer, 2001, 92:2501-2507.
  • 2Sacchi S, Kantarjian H M, O'Brien S, et al. Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the resuits of first salvage therapy with three different treatment approaches for 162 patients[J]. Cancer, 1999,86:2632-2641.
  • 3Kantarjian H, Talpaz M,O'Brien S, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosomepositive chronic phase chronic myeloid leukemia[J]. Blood, 2004,103: 2873-2878.
  • 4O'Brien S G, Guilhot F, Larson R A, et al. lmatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia [J]. N Engl J Med, 2003,348 : 994-1004.
  • 5江浩,陈珊珊,江滨,江倩,陆道培.格列卫治疗54例Ph阳性慢性髓细胞白血病[J].中华血液学杂志,2003,24(6):281-285. 被引量:13
  • 6李烽,陈捷,吴颖,李莉莉.格列卫致长时间严重骨髓抑制并发消化道出血1例[J].临床血液学杂志,2004,17(2):123-123. 被引量:1
  • 7Sawyers C, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase Ⅱ study[J]. Blood, 2002,99 : 3530-3539.
  • 8Hochhaus A,Kantarjian H M,Baccarani M,et al. Dasatinib in duces notable hematologic and cytogenetic responses in chronicphase chronic myeloid leukemia after failure of imatinib therapy [J]. Blood,2007,109:2303-2309.
  • 9Quintas-Cardama A,Kantarjian H M,Jones D, et al. Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure[J]. Blood,2007,109:497-499.
  • 10Mohi M G, Boulton C, Gu T L, et al. Combination of rapamy cin and protein tyrosine kinase (PTK) inhibitors for the treat ment of leukemias caused by oncogenic PTKs[J]. Proc Nat Acad Sci USA,2004,101:3130-3135.

共引文献12

同被引文献14

引证文献2

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部