摘要
目的建立一种简单易行的动脉粥样硬化的大鼠模型。方法雄性SD大鼠在高脂饮食的基础上给予维生素D3肌注和尼古丁灌胃,4周后观察各组动物血浆总胆固醇、高密度脂蛋白的变化和主动脉斑块形成情况。结果模型组血浆总胆固醇比正常对照组增高652%,高密度脂蛋白降低44%,且有明显的动脉斑快形成。结论高脂饮食辅以维生素D3肌注和尼古丁灌胃是一种简单快速的大鼠动脉粥样硬化模型的复制方法。
Objective To establish a new animal model for athemsclemstic in rots.Methods The male SD rats were randomly divided into normal control group and model group（ injected with vitamine D3 and administered nicotin by lavage based on highfat diet）. TC and HDL in plasma were detected after four weeks, speckle in aorta was also observed.Results 652% increased total cholesterol, 44% decreased high-density lipoprotein cholesterol in model group compared with that in control group（ P 〈 0.01 ）were found and there were a lot of plaques in model group aorta. Conclusion A kind of simple and speedy animal atherosclerostic model can be established by injecting with vitamine D3 and administering with nicotin based on high fat diet.
出处
《宁夏医学院学报》
2007年第4期350-351,F0004,共3页
Journal of Ningxia Medical College
基金
宁夏医学院校级课题资助项目(2006)
