摘要
目的观察老年大鼠氯胺酮麻醉后,学习记忆能力及痛阈的改变。方法14只老年大鼠(20月龄)随机分为2组,每组7只:对照组:生理盐水(NS)4mL/kg腹腔注射;氯胺酮组,氯胺酮(50mg/mL)4mL/kg腹腔注射。采用Morris水迷宫仪进行行为学检测,热水浴甩尾试验测定痛阈。结果随着训练次数的增加,两组逃避潜伏期呈逐渐缩短趋势;氯胺酮组:除第3d外,其余各d逃避潜伏期均长于对照组(P<0.05);撤除水下平台后游过原平台所在区域次数:氯胺酮组游过原平台区次数(2.7±2.1)次明显低于对照组(4.7±1.8)次(P<0.05);痛阈测定:从第2d开始,氯胺酮组各天甩尾潜伏期均明显长于对照组(P<0.05)。结论老年大鼠氯胺酮腹腔注射麻醉后,学习记忆能力明显下降,同时伴随痛阈的明显升高,持续至麻醉后5d仍未恢复。
[Objective] To observe the effects of ketamine hydrochloride （KTM） on abilities of learning and memory and pain sensibilites in aged rats. [Methods] Fourteen SD aged rats （20 months old） were randomly divided into 2 groups： G1 （n =7）： NS 4mL/kg ip; G2 （n =7）： KTM （50 mg/kg） 4 mL/kg ip. Abilities of learning and memory were observed by Morris Water Maze （MWM）. Pain sensibilites were determined by Tail-Fllck test with hot bath. [Results] Escape latency （EL）： The EL was getting shorter with more training. G2： EL was longer than G1 All days except D3 （P 〈0.05）; Times of swimming through the quadrant where the hidden platform had been： G2 was less than G1 （2.7±2.1） times vs （4.7±1.8） times （P 〈0.05）. Pain sensibilites： The tail-flicking time of G2 was longer than G1 significantly （P 〈0.05）. [Conclusions] Abilities of learning and memory and pain sensibilities in aged rats declined after anesthesia with KTM ip.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第15期1834-1836,共3页
China Journal of Modern Medicine
关键词
学习记忆
MORRIS水迷宫
痛阈
leaming and memory
morris water maze
pain sensibility
