摘要
目的:考察在不同温度条件下,氟尿嘧啶与辅酶A、酚磺乙胺的配伍稳定性。方法:用辅酶A、酚磺乙胺注射液与氟尿嘧啶注射液在0.9%氯化钠注射液中配伍,分别于25℃、37℃条件下,采用紫外分光光度法测定配伍后氟尿嘧啶的含量,同时观察外观变化及pH值。结果:不同温度条件下,氟尿嘧啶与酚磺乙胺注射液配伍液在12 h内颜色发生明显的变化,pH值和氟尿嘧啶的含量无明显变化;氟尿嘧啶与辅酶A注射液配伍液在12 h内性状、pH值和氟尿嘧啶含量均无明显变化。结论:氟尿嘧啶注射液可以与辅酶A配伍应用,但不能与酚磺乙胺配伍应用。
Objective： To study the stability of Fluorouracil injection with etamsylate injection and Coenzyme A injection at different temperatures （25℃, 37℃） in 12 hours. Methods： To mix fluorouracil injection with etamsylate injection and coenzyme A injection in 0.9% NaCl injection set at different temperatures （25℃, 37℃）, while examine the appearance and pH value, assay content of fluorouracil injection in the mixed solution by UV spectrophotometer. Results： The mixed solution of fluorouracil injection and Etamsylate injection at different temperatures （25℃, 37℃ ） during 12 hours, the appearance changed obviously, but pH value and fluorouracil content didn＇t change obviously, the mixed solution of fluorouracil injection and coenzyme A iniection at different temperatures （25℃, 37℃） during 12 hours, the appearance, pH value and fluorouracil content didn＇t change obviously. Conclusion： The fluorouracil injection and etamsylate injection is not compatible. But the fluorouracil injection and coenzyme A injection is compatible.
出处
《新疆医科大学学报》
CAS
2007年第7期725-726,共2页
Journal of Xinjiang Medical University
关键词
氟尿嘧啶
酚磺乙胺
辅酶A
配伍稳定性
fluorouracil injection
etamsylate injection
coenzyme A injection
compatibility
